Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD)
1_MALKQ 6_ EMAKS 11_ LLKTA 16_ SLSGR 21_ TKLLH 26_ QTGLS 31_ LYSTS 36_ HGFYE 41_ EEVKK 46_ TLQQF 51_ PGGSI 56_ DLQKE 61_ DNGIG 66_ ILTLN 71_ NPSRM 76_ NAFSG 81_ VMMLQ 86_ LLEKV 91_ IELEN 96_ WTEGK 101_ GLIVR 106_ GAKNT 111_ FSSGS 116_ DLNAV 121_ KSLGT 126_ PEDGM 131_ AVCMF 136_ MQNTL 141_ TRFMR 146_ LPLIS 151_ VALVQ 156_ GWALG 161_ GGAEF 166_ TTACD 171_ FRLMT 176_ PESKI 181_ RFVHK 186_ EMGII 191_ PSWGG 196_ TTRLV 201_ EIIGS 206_ RQALK 211_ VLSGA 216_ LKLDS 221_ KNALN 226_ IGMVE 231_ EVLQS 236_ SDETK 241_ SLEEA 246_ QEWLK 251_ QFIQG 256_ PPEVI 261_ RALKK 266_ SVCSG 271_ RELYL 276_ EEALQ 281_ NERDL 286_ LGTVW 291_ GGPAN 296_ LEAIA 301_KKGKF
1: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity)