Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698)
1_MAAGE 6_ PRSLL 11_ FFQKP 16_ VTFED 21_ VAVNF 26_ TQEEW 31_ DCLDA 36_ SQRVL 41_ YQDVM 46_ SETFK 51_ NLTSV 56_ ARIFL 61_ HKPEL 66_ ITKLE 71_ QEEEQ 76_ WRETR 81_ VLQAS 86_ QAGPP 91_ FFCYT 96_ CGKCF 101_ SRRSY 106_ LYSHQ 111_ FVHNP 116_ KLTNS 121_ CSQCG 126_ KLFRS 131_ PKSLS 136_ YHRRM 141_ HLGER 146_ PFCCT 151_ LCDKT 156_ YCDAS 161_ GLSRH 166_ RRVHL 171_ GYRPH 176_ SCSVC 181_ GKSFR 186_ DQSEL 191_ KRHQK 196_ IHQNQ 201_ EPVDG 206_ NQECT 211_ LRIPG 216_ TQAEF 221_ QTPIA 226_ RSQRS 231_ IQGLL 236_ DVNHA 241_ PVARS 246_ QEPIF 251_ RTEGP 256_ MAQNQ 261_ ASVLK 266_ NQAPV 271_ TRTQA 276_ PITGT 281_ LCQDA 286_ RSNSH 291_ PVKPS 296_ RLNVF 301_ CCPHC 306_ SLTFS 311_ KKSYL 316_ SRHQK 321_ AHLTE 326_ PPNYC 331_ FHCSK 336_ SFSSF 341_ SRLVR 346_ HQQTH 351_ WKQKS 356_ YLCPI 361_ CDLSF 366_ GEKEG 371_ LMDHW 376_ RGYKG 381_ KDLCQ 386_ SSHHK 391_ CRVIL 396_ GQWLG 401_ FSHDV 406_ PTMAG 411_ EEWKH 416_ GGDQS 421_ PPRIH 426_ TPRRR 431_ GLREK 436_ ACKGD 441_ KTKEA 446_VSILK
1: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity)