Zinc finger CCHC domain-containing protein 3
1_MATGG 6_ GAEEE 11_ RKRGR 16_ PQLLP 21_ PARPA 26_ ARGEE 31_ ADGGR 36_ EKMGW 41_ AQVVK 46_ NLAEK 51_ KGEFR 56_ EPRPP 61_ RREEE 66_ SGGGG 71_ GSAGL 76_ GGPAG 81_ LAAPD 86_ LGDFP 91_ PAGRG 96_ DPKGR 101_ RRDPA 106_ GEAVD 111_ PRKKK 116_ GAAEA 121_ GRRKK 126_ AEAAA 131_ AAMAT 136_ PARPG 141_ EAEDA 146_ AERPL 151_ QDEPA 156_ AAAGP 161_ GKGRF 166_ LVRIC 171_ FQGDE 176_ GACPT 181_ RDFVV 186_ GALIL 191_ RSIGM 196_ DPSDI 201_ YAVIQ 206_ IPGSR 211_ EFDVS 216_ FRSAE 221_ KLALF 226_ LRVYE 231_ EKREQ 236_ EDCWE 241_ NFVVL 246_ GRSKS 251_ SLKTL 256_ FILFR 261_ NETVD 266_ VEDIV 271_ TWLKR 276_ HCDVL 281_ AVPVK 286_ VTDRF 291_ GIWTG 296_ EYKCE 301_ IELRQ 306_ GEGGV 311_ RHLPG 316_ AFFLG 321_ AERGY 326_ SWYKG 331_ QPKTC 336_ FKCGS 341_ RTHMS 346_ GSCTQ 351_ DRCFR 356_ CGEEG 361_ HLSPY 366_ CRKGI 371_ VCNLC 376_ GKRGH 381_ AFAQC 386_ PKAVH 391_ NSVAA 396_QLTGV
1: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30135424, PubMed:30193849). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30135424, PubMed:30193849). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed:30193849)