Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18)
1_MKDCE 6_ YQQIS 11_ PGAAP 16_ LPASP 21_ GARRP 26_ GPAAS 31_ PTPGP 36_ GPAPP 41_ AAPAP 46_ PRWSS 51_ SGSGS 56_ GSGSG 61_ SLGRR 66_ PRRKW 71_ EVFPG 76_ RNRFY 81_ CGGRL 86_ MLAGH 91_ GGVFA 96_ LTLLL 101_ ILTTT 106_ GLFFV 111_ FDCPY 116_ LARKL 121_ TLAIP 126_ IIAAI 131_ LFFFV 136_ MSCLL 141_ QTSFT 146_ DPGIL 151_ PRATV 156_ CEAAA 161_ LEKQI 166_ DNTGS 171_ STYRP 176_ PPRTR 181_ EVLIN 186_ GQMVK 191_ LKYCF 196_ TCKMF 201_ RPPRT 206_ SHCSV 211_ CDNCV 216_ ERFDH 221_ HCPWV 226_ GNCVG 231_ RRNYR 236_ FFYAF 241_ ILSLS 246_ FLTAF 251_ IFACV 256_ VTHLT 261_ LRAQG 266_ SNFLS 271_ TLKET 276_ PASVL 281_ ELVIC 286_ FFSIW 291_ SILGL 296_ SGFHT 301_ YLVAS 306_ NLTTN 311_ EDIKG 316_ SWSSK 321_ RGGEA 326_ SVNPY 331_ SHKSI 336_ ITNCC 341_ AVLCG 346_ PLPPS 351_ LIDRR 356_ GFVQS 361_ DTVLP 366_ SPIRS 371_ DEPAC 376_ RAKPD 381_ASMVG
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942)