Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (pDCR) (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (Short chain dehydrogenase/reductase family 17C member 1)
1_MAQPP 6_ PDVEG 11_ DDCLP 16_ AYRHL 21_ FCPDL 26_ LRDKV 31_ AFITG 36_ GGSGI 41_ GFRIA 46_ EIFMR 51_ HGCHT 56_ VIASR 61_ SLPRV 66_ LTAAR 71_ KLAGA 76_ TGRRC 81_ LPLSM 86_ DVRAP 91_ PAVMA 96_ AVDQA 101_ LKEFG 106_ RIDIL 111_ INCAA 116_ GNFLC 121_ PAGAL 126_ SFNAF 131_ KTVMD 136_ IDTSG 141_ TFNVS 146_ RVLYE 151_ KFFRD 156_ HGGVI 161_ VNITA 166_ TLGNR 171_ GQALQ 176_ VHAGS 181_ AKAAV 186_ DAMTR 191_ HLAVE 196_ WGPQN 201_ IRVNS 206_ LAPGP 211_ ISGTE 216_ GLRRL 221_ GGPQA 226_ SLSTK 231_ VTASP 236_ LQRLG 241_ NKTEI 246_ AHSVL 251_ YLASP 256_ LASYV 261_ TGAVL 266_ VADGG 271_ AWLTF 276_ PNGVK 281_ GLPDF 286_ASFSA
1: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid