Palmitoyl-protein thioesterase ABHD10, mitochondrial (EC 3.1.2.22) (Acyl-protein thioesterase ABHD10) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10) (Mycophenolic acid acyl-glucuronide esterase, mitochondrial) (EC 3.1.1.93)
1_MAVAR 6_ LAAVA 11_ AWVPC 16_ RSWGW 21_ AAVPF 26_ GPHRG 31_ LSVLL 36_ ARIPQ 41_ RAPRW 46_ LPACR 51_ QKTSL 56_ SFLNR 61_ PDLPN 66_ LAYKK 71_ LKGKS 76_ PGIIF 81_ IPGYL 86_ SYMNG 91_ TKALA 96_ IEEFC 101_ KSLGH 106_ ACIRF 111_ DYSGV 116_ GSSDG 121_ NSEES 126_ TLGKW 131_ RKDVL 136_ SIIDD 141_ LADGP 146_ QILVG 151_ SSLGG 156_ WLMLH 161_ AAIAR 166_ PEKVV 171_ ALIGV 176_ ATAAD 181_ TLVTK 186_ FNQLP 191_ VELKK 196_ EVEMK 201_ GVWSM 206_ PSKYS 211_ EEGVY 216_ NVQYS 221_ FIKEA 226_ EHHCL 231_ LHSPI 236_ PVNCP 241_ IRLLH 246_ GMKDD 251_ IVPWH 256_ TSMQV 261_ ADRVL 266_ STDVD 271_ VILRK 276_ HSDHR 281_ MREKA 286_ DIQLL 291_ VYTID 296_ DLIDK 301_LSTIV
1: Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833). Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (PubMed:22294686)