Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR)
1_MTAVN 6_ VALIR 11_ DTKWL 16_ TLEVC 21_ REFQR 26_ GTCSR 31_ ADADC 36_ KFAHP 41_ PRVCH 46_ VENGR 51_ VVACF 56_ DSLKG 61_ RCTRE 66_ NCKYL 71_ HPPPH 76_ LKTQL 81_ EINGR 86_ NNLIQ 91_ QKTAA 96_ AMFAQ 101_ QMQLM 106_ LQNAQ 111_ MSSLG 116_ SFPMT 121_ PSIPA 126_ NPPMA 131_ FNPYI 136_ PHPGM 141_ GLVPA 146_ ELVPN 151_ TPVLI 156_ PGNPP 161_ LAMPG 166_ AVGPK 171_ LMRSD 176_ KLEVC 181_ REFQR 186_ GNCTR 191_ GENDC 196_ RYAHP 201_ TDASM 206_ IEASD 211_ NTVTI 216_ CMDYI 221_ KGRCS 226_ REKCK 231_ YFHPP 236_ AHLQA 241_ RLKAA 246_ HHQMN 251_ HSAAS 256_ AMALQ 261_ PGTLQ 266_ LIPKR 271_ SALEK 276_ PNGAT 281_ PVFNP 286_ TVFHC 291_ QQALT 296_ NLQLP 301_ QPAFI 306_ PAGPI 311_ LCMAP 316_ ASNIV 321_ PMMHG 326_ ATPTT 331_ VSAAT 336_ TPATS 341_ VPFAA 346_PTTGN
1: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction