Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN)
1_MSQEG 6_ VELEK 11_ SVRRL 16_ REKFH 21_ GKVSS 26_ KKAGA 31_ LMRKF 36_ GSDHT 41_ GVGRS 46_ IVYGV 51_ KQKDG 56_ QELSN 61_ DLDAQ 66_ DPPED 71_ MKQDR 76_ DIQAV 81_ ATSLL 86_ PLTEA 91_ NLRMF 96_ QRAQD 101_ DLIPA 106_ VDRQF 111_ ACSSC 116_ DHVWW 121_ RRVPQ 126_ RKEVS 131_ RCRKC 136_ RKRYE 141_ PVPAD 146_ KMWGL 151_ AEFHC 156_ PKCRH 161_ NFRGW 166_ AQMGS 171_ PSPCY 176_ GCGFP 181_ VYPTR 186_ ILPPR 191_ WDRDP 196_ DRRST 201_ HTHSC 206_ SAADC 211_ YNRRE 216_ PHVPG 221_ TSCAH 226_ PKSRK 231_ QNHLP 236_ KVLHP 241_ SNPHI 246_ SSGST 251_ VATCL 256_ SQGGL 261_ LEDLD 266_ NLILE 271_ DLKEE 276_ EEEEE 281_ EVEDE 286_EGGPR
1: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Also interrupts Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway (PubMed:32150556). Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus (PubMed:26735137, PubMed:27974568, PubMed:30944177, PubMed:32294532). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568)
2: Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes