Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9)
1_MDDFI 6_ SISLL 11_ SLAML 16_ VGCYV 21_ AGIIP 26_ LAVNF 31_ SEERL 36_ KLVTV 41_ LGAGL 46_ LCGTA 51_ LAVIV 56_ PEGVH 61_ ALYED 66_ ILEGK 71_ HHQAS 76_ ETHNV 81_ IASDK 86_ AAEKS 91_ VVHEH 96_ EHSHD 101_ HTQLH 106_ AYIGV 111_ SLVLG 116_ FVFML 121_ LVDQI 126_ GNSHV 131_ HSTDD 136_ PEAAR 141_ SSNSK 146_ ITTTL 151_ GLVVH 156_ AAADG 161_ VALGA 166_ AASTS 171_ QTSVQ 176_ LIVFV 181_ AIMLH 186_ KAPAA 191_ FGLVS 196_ FLMHA 201_ GLERN 206_ RIRKH 211_ LLVFA 216_ LAAPV 221_ MSMVT 226_ YLGLS 231_ KSSKE 236_ ALSEV 241_ NATGV 246_ AMLFS 251_ AGTFL 256_ YVATV 261_ HVLPE 266_ VGGIG 271_ HSHKP 276_ DATGG 281_ RGLSR 286_ LEVAA 291_ LVLGC 296_ LIPLI 301_LSVGH
1: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, PubMed:25014355, PubMed:28219737). Participates in the zinc ions efflux out of the secretory compartments (PubMed:19420709). Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (PubMed:23505453). Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription (PubMed:34555425). Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (PubMed:25014355, PubMed:28219737)