Lysosomal cobalamin transport escort protein LMBD1 (LMBD1) (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein)
1_MATSG 6_ AASAE 11_ LVIGW 16_ CIFGL 21_ LLLAI 26_ LAFCW 31_ IYVRK 36_ YQSRR 41_ ESEVV 46_ STITA 51_ IFSLA 56_ IALIT 61_ SALLP 66_ VDIFL 71_ VSYMK 76_ NQNGT 81_ FKDWA 86_ NANVS 91_ RQIED 96_ TVLYG 101_ YYTLY 106_ SVILF 111_ CVFFW 116_ IPFVY 121_ FYYEE 126_ KDDDD 131_ TSKCT 136_ QIKTA 141_ LKYTL 146_ GFVVI 151_ CALLL 156_ LVGAF 161_ VPLNV 166_ PNNKN 171_ STEWE 176_ KVKSL 181_ FEELG 186_ SSHGL 191_ AALSF 196_ SISSL 201_ TLIGM 206_ LAAIT 211_ YTAYG 216_ MSALP 221_ LNLIK 226_ GTRSA 231_ AYERL 236_ ENTED 241_ IEEVE 246_ QHIQT 251_ IKSKS 256_ KDGRP 261_ LPARD 266_ KRALK 271_ QFEER 276_ LRTLK 281_ KRERH 286_ LEFIE 291_ NSWWT 296_ KFCGA 301_ LRPLK 306_ IVWGI 311_ FFILV 316_ ALLFV 321_ ISLFL 326_ SNLDK 331_ ALHSA 336_ GIDSG 341_ FIIFG 346_ ANLSN 351_ PLNML 356_ LPLLQ 361_ TVFPL 366_ DYILI 371_ TIIIM 376_ YFIFT 381_ SMAGI 386_ RNIGI 391_ WFFWI 396_ RLYKI 401_ RRGRT 406_ RPQAL 411_ LFLCM 416_ ILLLI 421_ VLHTS 426_ YMIYS 431_ LAPQY 436_ VMYGS 441_ QNYLI 446_ ETNIT 451_ SDNHK 456_ GNSTL 461_ SVPKR 466_ CDADA 471_ PEDQC 476_ TVTRT 481_ YLFLH 486_ KFWFF 491_ SAAYY 496_ FGNWA 501_ FLGVF 506_ LIGLI 511_ VSCCK 516_ GKKSV 521_ IEGVD 526_ EDSDI 531_SDDEP
1: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed:27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity)
2: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV)