Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (EC 3.5.1.23) (Alkaline dihydroceramidase SB89) (Alkaline phytoceramidase) (aPHC)
1_MAPAA 6_ DREGY 11_ WGPTT 16_ STLDW 21_ CEENY 26_ SVTWY 31_ IAEFW 36_ NTVSN 41_ LIMII 46_ PPMFG 51_ AVQSV 56_ RDGLE 61_ KRYIA 66_ SYLAL 71_ TVVGM 76_ GSWCF 81_ HMTLK 86_ YEMQL 91_ LDELP 96_ MIYSC 101_ CIFVY 106_ CMFEC 111_ FKIKN 116_ SVNYH 121_ LLFTL 126_ VLFSL 131_ IVTTV 136_ YLKVK 141_ EPIFH 146_ QVMYG 151_ MLVFT 156_ LVLRS 161_ IYIVT 166_ WVYPW 171_ LRGLG 176_ YTSLG 181_ IFLLG 186_ FLFWN 191_ IDNIF 196_ CESLR 201_ NFRKK 206_ VPPII 211_ GITTQ 216_ FHAWW 221_ HILTG 226_ LGSYL 231_ HILFS 236_ LYTRT 241_ LYLRY 246_ RPKVK 251_ FLFGI 256_ WPVIL 261_FEPLR
1: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:11356846, PubMed:20068046, PubMed:20207939, PubMed:26792856, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity)