Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog)
1_MEGSF 6_ SDGGA 11_ LPEGL 16_ AEEAE 21_ PQGAA 26_ WSGDS 31_ GTVSQ 36_ SHSSA 41_ SGPWE 46_ DEGAE 51_ DGAPG 56_ RDLPL 61_ LRRAA 66_ AGYAA 71_ CLLPG 76_ AGARP 81_ EVEAL 86_ DASLE 91_ DLLTR 96_ VDEFV 101_ GMLDM 106_ LRGDS 111_ SHVVS 116_ EGVPR 121_ IHAKA 126_ AEMRR 131_ IYSRI 136_ DRLEA 141_ FVRMV 146_ GGRVA 151_ RMEEQ 156_ VTKAE 161_ AELGT 166_ FPRAF 171_ KKLLH 176_ TMNVP 181_ SLFSK 186_ SAPSR 191_ PQQAG 196_ YEAPV 201_ LFRTE 206_ DYFPC 211_CSERP
1: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking