1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon)
1_MLLSL 6_ VLHTY 11_ SMRYL 16_ LPSVV 21_ LLGTA 26_ PTYVL 31_ AWGVW 36_ RLLSA 41_ FLPAR 46_ FYQAL 51_ DDRLY 56_ CVYQS 61_ MVLFF 66_ FENYT 71_ GVQIL 76_ LYGDL 81_ PKNKE 86_ NIIYL 91_ ANHQS 96_ TVDWI 101_ VADIL 106_ AIRQN 111_ ALGHV 116_ RYVLK 121_ EGLKW 126_ LPLYG 131_ CYFAQ 136_ HGGIY 141_ VKRSA 146_ KFNEK 151_ EMRNK 156_ LQSYV 161_ DAGTP 166_ MYLVI 171_ FPEGT 176_ RYNPE 181_ QTKVL 186_ SASQA 191_ FAAQR 196_ GLAVL 201_ KHVLT 206_ PRIKA 211_ THVAF 216_ DCMKN 221_ YLDAI 226_ YDVTV 231_ VYEGK 236_ DDGGQ 241_ RRESP 246_ TMTEF 251_ LCKEC 256_ PKIHI 261_ HIDRI 266_ DKKDV 271_ PEEQE 276_ HMRRW 281_ LHERF 286_ EIKDK 291_ MLIEF 296_ YESPD 301_ PERRK 306_ RFPGK 311_ SVNSK 316_ LSIKK 321_ TLPSM 326_ LILSG 331_ LTAGM 336_ LMTDA 341_ GRKLY 346_ VNTWI 351_ YGTLL 356_GCLWV
1: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190)