Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)
1_MSQEG 6_ DYGRW 11_ TISSS 16_ DESEE 21_ EKPKP 26_ DKPST 31_ SSLLC 36_ ARQGA 41_ ANEPR 46_ YTCSE 51_ AQKAA 56_ HKRKI 61_ SPVKF 66_ SNTDS 71_ VLPPK 76_ RQKSG 81_ SQEDL 86_ GWCLS 91_ SSDDE 96_ LQPEM 101_ PQKQA 106_ EKVVI 111_ KKEKD 116_ ISAPN 121_ DGTAQ 126_ RTENH 131_ GAPAC 136_ HRLKE 141_ EEDEY 146_ ETSGE 151_ GQDIW 156_ DMLDK 161_ GNPFQ 166_ FYLTR 171_ VSGVK 176_ PKYNS 181_ GALHI 186_ KDILS 191_ PLFGT 196_ LVSSA 201_ QFNYC 206_ FDVDW 211_ LVKQY 216_ PPEFR 221_ KKPIL 226_ LVHGD 231_ KREAK 236_ AHLHA 241_ QAKPY 246_ ENISL 251_ CQAKL 256_ DIAFG 261_ THHTK 266_ MMLLL 271_ YEEGL 276_ RVVIH 281_ TSNLI 286_ HADWH 291_ QKTQG 296_ IWLSP 301_ LYPRI 306_ ADGTH 311_ KSGES 316_ PTHFK 321_ ADLIS 326_ YLMAY 331_ NAPSL 336_ KEWID 341_ VIHKH 346_ DLSET 351_ NVYLI 356_ GSTPG 361_ RFQGS 366_ QKDNW 371_ GHFRL 376_ KKLLK 381_ DHASS 386_ MPNAE 391_ SWPVV 396_ GQFSS 401_ VGSLG 406_ ADESK 411_ WLCSE 416_ FKESM 421_ LTLGK 426_ ESKTP 431_ GKSSV 436_ PLYLI 441_ YPSVE 446_ NVRTS 451_ LEGYP 456_ AGGSL 461_ PYSIQ 466_ TAEKQ 471_ NWLHS 476_ YFHKW 481_ SAETS 486_ GRSNA 491_ MPHIK 496_ TYMRP 501_ SPDFS 506_ KIAWF 511_ LVTSA 516_ NLSKA 521_ AWGAL 526_ EKNGT 531_ QLMIR 536_ SYELG 541_ VLFLP 546_ SAFGL 551_ DSFKV 556_ KQKFF 561_ AGSQE 566_ PMATF 571_ PVPYD 576_ LPPEL 581_ YGSKD 586_ RPWIW 591_ NIPYV 596_ KAPDT 601_HGNMW
1: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate