Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)
1_MSLVP 6_ ATNYI 11_ YTPLN 16_ QLKGG 21_ TIVNV 26_ YGVVK 31_ FFKPP 36_ YLSKG 41_ TDYCS 46_ VVTIV 51_ DQTNV 56_ KLTCL 61_ LFSGN 66_ YEALP 71_ IIYKN 76_ GDIVR 81_ FHRLK 86_ IQVYK 91_ KETQG 96_ ITSSG 101_ FASLT 106_ FEGTL 111_ GAPII 116_ PRTSS 121_ KYFNF 126_ TTEDH 131_ KMVEA 136_ LRVWA 141_ STHMS 146_ PSWTL 151_ LKLCD 156_ VQPMQ 161_ YFDLT 166_ CQLLG 171_ KAEVD 176_ GASFL 181_ LKVWD 186_ GTRTP 191_ FPSWR 196_ VLIQD 201_ LVLEG 206_ DLSHI 211_ HRLQN 216_ LTIDI 221_ LVYDN 226_ HVHVA 231_ RSLKV 236_ GSFLR 241_ IYSLH 246_ TKLQS 251_ MNSEN 256_ QTMLS 261_ LEFHL 266_ HGGTS 271_ YGRGI 276_ RVLPE 281_ SNSDV 286_ DQLKK 291_ DLESA 296_ NLTAN 301_ QHSDV 306_ ICQSE 311_ PDDSF 316_ PSSGS 321_ VSLYE 326_ VERCQ 331_ QLSAT 336_ ILTDH 341_ QYLER 346_ TPLCA 351_ ILKQK 356_ APQQY 361_ RIRAK 366_ LRSYK 371_ PRRLF 376_ QSVKL 381_ HCPKC 386_ HLLQE 391_ VPHEG 396_ DLDII 401_ FQDGA 406_ TKTPD 411_ VKLQN 416_ TSLYD 421_ SKIWT 426_ TKNQK 431_ GRKVA 436_ VHFVK 441_ NNGIL 446_ PLSNE 451_ CLLLI 456_ EGGTL 461_ SEICK 466_ LSNKF 471_ NSVIP 476_ VRSGH 481_ EDLEL 486_ LDLSA 491_ PFLIQ 496_ GTIHH 501_ YGCKQ 506_ CSSLR 511_ SIQNL 516_ NSLVD 521_ KTSWI 526_ PSSVA 531_ EALGI 536_ VPLQY 541_ VFVMT 546_ FTLDD 551_ GTGVL 556_ EAYLM 561_ DSDKF 566_ FQIPA 571_ SEVLM 576_ DDDLQ 581_ KSVDM 586_ IMDMF 591_ CPPGI 596_ KIDAY 601_ PWLEC 606_ FIKSY 611_ NVTNG 616_ TDNQI 621_ CYQIF 626_DTTVA
1: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity