TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1)
1_MAEGE 6_ DVPPL 11_ PTSSG 16_ DGWEK 21_ DLEEA 26_ LEAGG 31_ CDLET 36_ LRNII 41_ QGRPL 46_ PADLR 51_ AKVWK 56_ IALNV 61_ AGKGD 66_ SLASW 71_ DGILD 76_ LPEQN 81_ TIHKD 86_ CLQFI 91_ DQLSV 96_ PEEKA 101_ AELLL 106_ DIESV 111_ ITFYC 116_ KSRNI 121_ KYSTS 126_ LSWIH 131_ LLKPL 136_ VHLQL 141_ PRSDL 146_ YNCFY 151_ AIMNK 156_ YIPRD 161_ CSQKG 166_ RPFHL 171_ FRLLI 176_ QYHEP 181_ ELCSY 186_ LDTKK 191_ ITPDS 196_ YALNW 201_ LGSLF 206_ ACYCS 211_ TEVTQ 216_ AIWDG 221_ YLQQA 226_ DPFFI 231_ YFLML 236_ IILVN 241_ AKEVI 246_ LTQES 251_ DSKEE 256_ VIKFL 261_ ENTPS 266_ SLNIE 271_ DIEDL 276_ FSLAQ 281_ YYCSK 286_ TPASF 291_ RKDNH 296_ HLFGS 301_ TLLGI 306_ KDDDA 311_ DLSQA 316_ LCLAI 321_ SVSEI 326_ LQANQ 331_ LQGEG 336_ VRFFV 341_ VDCRP 346_ AEQYN 351_ AGHLS 356_ TAFHL 361_ DSDLM 366_ LQNPS 371_ EFAQS 376_ VKSLL 381_ EAQKQ 386_ SIESG 391_ SIAGG 396_ EHLCF 401_ MGSGR 406_ EEEDM 411_ YMNMV 416_ LAHFL 421_ QKNKE 426_ YVSIA 431_ SGGFM 436_ ALQQH 441_ LADIN 446_ VDGPE 451_ NGYGH 456_ WIAST 461_ SGSRS 466_ SINSV 471_ DGESP 476_ NGSSD 481_ RGMKS 486_ LVNKM 491_ TVALK 496_ TKSVN 501_ VREKV 506_ ISFIE 511_ NTSTP 516_ VDRMS 521_ FNLPW 526_ PDRSC 531_ TERHV 536_ SSSDR 541_ VGKPY 546_ RGVKP 551_ VFSIG 556_ DEEEY 561_ DTDEI 566_ DSSSM 571_ SDDDR 576_ KEVVN 581_ IQTWI 586_ NKPDV 591_ KHHFP 596_ CKEVK 601_ ESGHM 606_ FPSHL 611_ LVTAT 616_ HMYCL 621_ REIVS 626_ RKGLA 631_ YIQSR 636_ QALNS 641_ VVKIT 646_ SKKKH 651_ PELIT 656_ FKYGN 661_ SSASG 666_ IEILA 671_ IERYL 676_ IPNAG 681_ DATKA 686_ IKQQI 691_MKVLD
1: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity)