DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1)
1_MKVKM 6_ LSRNP 11_ DNYVR 16_ ETKLD 21_ LQRVP 26_ RNYDP 31_ ALHPF 36_ EVPRE 41_ YIRAL 46_ NATKL 51_ ERVFA 56_ KPFLA 61_ SLDGH 66_ RDGVN 71_ CLAKH 76_ PEKLA 81_ TVLSG 86_ ACDGE 91_ VRIWN 96_ LTQRN 101_ CIRTI 106_ QAHEG 111_ FVRGI 116_ CTRFC 121_ GTSFF 126_ TVGDD 131_ KTVKQ 136_ WKMDG 141_ PGYGD 146_ EEEPL 151_ HTILG 156_ KTVYT 161_ GIDHH 166_ WKEAV 171_ FATCG 176_ QQVDI 181_ WDEQR 186_ TNPIC 191_ SMTWG 196_ FDSIS 201_ SVKFN 206_ PIETF 211_ LLGSC 216_ ASDRN 221_ IVLYD 226_ MRQAT 231_ PLKKV 236_ ILDMR 241_ TNTIC 246_ WNPME 251_ AFIFT 256_ AANED 261_ YNLYT 266_ FDMRA 271_ LDTPV 276_ MVHMD 281_ HVSAV 286_ LDVDY 291_ SPTGK 296_ EFVSA 301_ SFDKS 306_ IRIFP 311_ VDKSR 316_ SREVY 321_ HTKRM 326_ QHVIC 331_ VKWTS 336_ DSKYI 341_ MCGSD 346_ EMNIR 351_ LWKAN 356_ ASEKL 361_ GVLTS 366_ REKAA 371_ KDYNQ 376_ KLKEK 381_ FQHYP 386_ HIKRI 391_ ARHRH 396_ LPKSI 401_ YSQIQ 406_ EQRIM 411_ KEARR 416_ RKEVN 421_ RIKHS 426_ KPGSV 431_ PLVSE 436_KKKHV
1: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition (PubMed:30283081)
2: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:16949367, PubMed:30111536, PubMed:31492966). Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979). Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536). Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966). Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity)