Transmembrane protein 100
1_MTEEP 6_ IKEIL 11_ GAPKA 16_ HMAAT 21_ MEKSP 26_ KSEVV 31_ ITTVP 36_ LVSEI 41_ QLMAA 46_ TGGTE 51_ LSCYR 56_ CIIPF 61_ AVVVF 66_ IAGIV 71_ VTAVA 76_ YSFNS 81_ HGSII 86_ SIFGL 91_ VVLSS 96_ GLFLL 101_ ASSAL 106_ CWKVR 111_ QRSKK 116_ AKRRE 121_ SQTAL 126_VANQR
1: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex