MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4)
1_MGEAE 6_ VGGGG 11_ AAGDK 16_ GPGEA 21_ ATSPA 26_ EETVV 31_ WSPEV 36_ EVCLF 41_ HAMLG 46_ HKPVG 51_ VNRHF 56_ HMICI 61_ RDKFS 66_ QNIGR 71_ QVPSK 76_ VIWDH 81_ LSTMY 86_ DMQAL 91_ HESEI 96_ LPFPN 101_ PERNF 106_ VLPEE 111_ IIQEV 116_ REGKV 121_ MIEEE 126_ MKEEM 131_ KEDVD 136_ PHNGA 141_ DDVFS 146_ SSGSL 151_ GKASE 156_ KSSKD 161_ KEKNS 166_ SDLGC 171_ KEGAD 176_ KRKRS 181_ RVTDK 186_ VLTAN 191_ SNPSS 196_PSAAK
1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage