E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38)
1_MQEQE 6_ IGFIS 11_ KYNEG 16_ LCVNT 21_ DPVSI 26_ LTSIL 31_ DMSLH 36_ RQMGS 41_ DRDLQ 46_ SSASS 51_ VSLPS 56_ VKKAP 61_ KKRRI 66_ SIGSL 71_ FRRKK 76_ DNKRK 81_ SRELN 86_ GGVDG 91_ IASIE 96_ SIHSE 101_ MCTDK 106_ NSIFS 111_ TNTSS 116_ DNGLT 121_ SISKQ 126_ IGDFI 131_ ECPLC 136_ LLRHS 141_ KDRFP 146_ DIMTC 151_ HHRSC 156_ VDCLR 161_ QYLRI 166_ EISES 171_ RVNIS 176_ CPECT 181_ ERFNP 186_ HDIRL 191_ ILSDD 196_ VLMEK 201_ YEEFM 206_ LRRWL 211_ VADPD 216_ CRWCP 221_ APDCG 226_ YAVIA 231_ FGCAS 236_ CPKLT 241_ CGREG 246_ CGTEF 251_ CYHCK 256_ QIWHP 261_ NQTCD 266_ AARQE 271_ RAQSL 276_ RLRTI 281_ RSSSI 286_ SYSQE 291_ SGAAA 296_ DDIKP 301_ CPRCA 306_ AYIIK 311_ MNDGS 316_ CNHMT 321_ CAVCG 326_ CEFCW 331_ LCMKE 336_ ISDLH 341_ YLSPS 346_ GCTFW 351_ GKKPW 356_ SRKKK 361_ ILWQL 366_ GTLVG 371_ APVGI 376_ ALIAG 381_ IAIPA 386_ MIIGI 391_ PVYVG 396_ RKIHN 401_ RYEGK 406_ DVSKH 411_ KRNLA 416_ IAGGV 421_ TLSVI 426_ VSPVV 431_ AAVTV 436_ GIGVP 441_ IMLAY 446_ VYGVV 451_ PISLC 456_ RSGGC 461_ GVSAG 466_ NGKGV 471_ RIEFD 476_ DENDI 481_ NVGGT 486_ NTAVD 491_ TTSVA 496_ EARHN 501_ PSIGE 506_ GSVGG 511_ LTGSL 516_ SASGS 521_ HMDRI 526_ GAIRD 531_ NLSET 536_ ASTMA 541_ LAGAS 546_ ITGSL 551_ SGSAM 556_ VNCFN 561_ RLEVQ 566_ ADVQK 571_ ERYSL 576_ SGESG 581_ TVSLG 586_ TVSDN 591_ ASTKA 596_ MAGSI 601_ LNSYI 606_ PLDKE 611_ GNSME 616_ VQVDI 621_ ESKPS 626_ KFRHN 631_ SGSSS 636_ VDDGS 641_ ATRSH 646_ AGGSS 651_ SGLPE 656_ GKSSA 661_ TKWSK 666_ EATAG 671_ KKSKS 676_ GKLRK 681_ KGNMK 686_ INETR 691_ EDMDA 696_ QLLEQ 701_ QSTNS 706_ SEFEA 711_ PSLSD 716_ SMPSV 721_ ADSHS 726_ SHFSE 731_ FSCSD 736_ LESMK 741_ TSCSH 746_ GSSDY 751_ HTRFA 756_ TVNIL 761_ PEVEN 766_ DRLEN 771_ SPHQC 776_ SISVV 781_ TQTAS 786_ CSEVS 791_ QLNHI 796_ AEEHG 801_ NNGIK 806_ PNVDL 811_ YFGDA 816_ LKETN 821_ NNHSH 826_ QTMEL 831_KVAIQ
1: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection