Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
1_MGGAV 6_ SAGED 11_ NDELI 16_ DNLKE 21_ AQYIR 26_ TELVE 31_ QAFRA 36_ IDRAD 41_ YYLEE 46_ FKENA 51_ YKDLA 56_ WKHGN 61_ IHLSA 66_ PCIYS 71_ EVMEA 76_ LDLQP 81_ GLSFL 86_ NLGSG 91_ TGYLS 96_ SMVGL 101_ ILGPF 106_ GVNHG 111_ VELHS 116_ DVIEY 121_ AKQKL 126_ DFFIR 131_ TSDSF 136_ DKFDF 141_ CEPSF 146_ VTGNC 151_ LEISP 156_ DCSQY 161_ DRVYC 166_ GAGVQ 171_ KEHEE 176_ YMKNL 181_ LKVGG 186_ ILVMP 191_ LEEKL 196_ TKITR 201_ TGPSA 206_ WETKK 211_ ILAVS 216_ FAPLI 221_ QPCHS 226_ ESGKS 231_ RLVQL 236_ PPVAV 241_ RSLQD 246_ LARIA 251_ IRGTI 256_ KKIIH 261_ QETVS 266_ KNGNG 271_ LKNTP 276_ RFKRR 281_ RVRRR 286_ RMETI 291_ VFLDK 296_ EVFAS 301_ RISNP 306_ SDDNS 311_ CEDLE 316_ EERRE 321_ EEEKT 326_ PPETK 331_ PDPPV 336_ NFLRQ 341_ KVLSL 346_ PLPDP 351_ LKYYL 356_LYYRE
1: May act as a substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May bind to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but probably does not display methyltransferase activity