Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74)
1_MKLYC 6_ LSGHP 11_ TLPCN 16_ VLKFK 21_ STTIM 26_ LDCGL 31_ DMTST 36_ LNFLP 41_ LPLVQ 46_ SPRLS 51_ NLPGW 56_ SLKDG 61_ NAFLD 66_ KELKE 71_ CSGHV 76_ FVDSV 81_ PEFCL 86_ PETEL 91_ IDLST 96_ VDVIL 101_ ISNYH 106_ CMMAL 111_ PYITE 116_ HTGFT 121_ GTVYA 126_ TEPTV 131_ QIGRL 136_ LMEEL 141_ VNFIE 146_ RVPKA 151_ QSASL 156_ WKNKD 161_ IQRLL 166_ PSPLK 171_ DAVEV 176_ STWRR 181_ CYTMQ 186_ EVNSA 191_ LSKIQ 196_ LVGYS 201_ QKIEL 206_ FGAVQ 211_ VTPLS 216_ SGYAL 221_ GSSNW 226_ IIQSH 231_ YEKVS 236_ YVSGS 241_ SLLTT 246_ HPQPM 251_ DQASL 256_ KNSDV 261_ LVLTG 266_ LTQIP 271_ TANPD 276_ GMVGE 281_ FCSNL 286_ ALTVR 291_ NGGNV 296_ LVPCY 301_ PSGVI 306_ YDLLE 311_ CLYQY 316_ IDSAG 321_ LSSVP 326_ LYFIS 331_ PVANS 336_ SLEFS 341_ QIFAE 346_ WLCHN 351_ KQSKV 356_ YLPEP 361_ PFPHA 366_ ELIQT 371_ NKLKH 376_ YPSIH 381_ GDFSN 386_ DFRQP 391_ CVVFT 396_ GHPSL 401_ RFGDV 406_ VHFME 411_ LWGKS 416_ SLNTV 421_ IFTEP 426_ DFSYL 431_ EALAP 436_ YQPLA 441_ MKCIY 446_ CPIDT 451_ RLNFI 456_ QVSKL 461_ LKEVQ 466_ PLHVV 471_ CPEQY 476_ TQPPP 481_ AQSHR 486_ MDLMI 491_ DCQPP 496_ AMSYR 501_ RAEVL 506_ ALPFK 511_ RRYEK 516_ IEIMP 521_ ELADS 526_ LVPME 531_ IKPGI 536_ SLATV 541_ SAVLH 546_ TKDNK 551_ HLLQP 556_ PPRPA 561_ QPTSG 566_ KKRKR 571_ VSDDV 576_ PDCKV 581_ LKPLL 586_ SGSIP 591_ VEQFV 596_ QTLEK 601_ HGFSD 606_ IKVED 611_ TAKGH 616_ IVLLQ 621_ EAETL 626_ IQIEE 631_ DSTHI 636_ ICDND 641_ EMLRV 646_ RLRDL 651_VLKFL
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:22252320, PubMed:26308897, PubMed:30737432). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)