NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)
1_MARRR 6_ SQRVC 11_ ASGPS 16_ MLNSA 21_ RGAPE 26_ LLRGT 31_ ATNAE 36_ VSAAA 41_ AGATG 46_ SEELP 51_ PGDRG 56_ CRNGG 61_ GRGPA 66_ ATTSS 71_ TGVAV 76_ GAEHG 81_ EDSLS 86_ RKPDP 91_ EPGRM 96_ DHHQP 101_ GTGRY 106_ QVLLN 111_ EEDNS 116_ ESSAI 121_ EQPPT 126_ SNPAP 131_ QIVQA 136_ ASSAP 141_ ALETD 146_ SSPPP 151_ YSSIT 156_ VEVPT 161_ TSDTE 166_ VYGEF 171_ YPVPP 176_ PYSVA 181_ TSLPT 186_ YDEAE 191_ KAKAA 196_ AMAAA 201_ AAETS 206_ QRIQE 211_ EECPP 216_ RDDFS 221_ DADQL 226_ RVGND 231_ GIFML 236_ AFFMA 241_ FIFNW 246_ LGFCL 251_ SFCIT 256_ NTIAG 261_ RYGAI 266_ CGFGL 271_ SLIKW 276_ ILIVR 281_ FSDYF 286_ TGYFN 291_ GQYWL 296_ WWIFL 301_ VLGLL 306_ LFFRG 311_ FVNYL 316_ KVRNM 321_ SESMA 326_ AAHRT 331_RYFFL
1: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity)