Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A)
1_MAMNY 6_ NAKDE 11_ VDGGP 16_ PCAPG 21_ GTAKT 26_ RRPDN 31_ TAFKQ 36_ QRLPA 41_ WQPIL 46_ TAGTV 51_ LPIFF 56_ IIGLI 61_ FIPIG 66_ IGIFV 71_ TSNNI 76_ REIEI 81_ DYTGT 86_ EPSSP 91_ CNKCL 96_ SPDVT 101_ PCFCT 106_ INFTL 111_ EKSFE 116_ GNVFM 121_ YYGLS 126_ NFYQN 131_ HRRYV 136_ KSRDD 141_ SQLNG 146_ DSSAL 151_ LNPSK 156_ ECEPY 161_ RRNED 166_ KPIAP 171_ CGAIA 176_ NSMFN 181_ DTLEL 186_ FLIGN 191_ DSYPI 196_ PIALK 201_ KKGIA 206_ WWTDK 211_ NVKFR 216_ NPPGG 221_ DNLEE 226_ RFKGT 231_ TKPVN 236_ WLKPV 241_ YMLDS 246_ DPDNN 251_ GFINE 256_ DFIVW 261_ MRTAA 266_ LPTFR 271_ KLYRL 276_ IERKS 281_ DLHPT 286_ LPAGR 291_ YSLNV 296_ TYNYP 301_ VHYFD 306_ GRKRM 311_ ILSTI 316_ SWMGG 321_ KNPFL 326_ GIAYI 331_ AVGSI 336_ SFLLG 341_ VVLLV 346_ INHKY 351_ RNSSN 356_TADIT
1: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations