SET domain-containing protein 4 (EC 2.1.1.-) (EC 2.1.1.364)
1_MQKGK 6_ GRTSR 11_ IRRRK 16_ LCGSS 21_ ESRGV 26_ NESHK 31_ SEFIE 36_ LRKWL 41_ KARKF 46_ QDSNL 51_ APACF 56_ PGTGR 61_ GLMSQ 66_ TSLQE 71_ GQMII 76_ SLPES 81_ CLLTT 86_ DTVIR 91_ SYLGA 96_ YITKW 101_ KPPPS 106_ PLLAL 111_ CTFLV 116_ SEKHA 121_ GHRSL 126_ WKPYL 131_ EILPK 136_ AYTCP 141_ VCLEP 146_ EVVNL 151_ LPKSL 156_ KAKAE 161_ EQRAH 166_ VQEFF 171_ ASSRD 176_ FFSSL 181_ QPLFA 186_ EAVDS 191_ IFSYS 196_ ALLWA 201_ WCTVN 206_ TRAVY 211_ LRPRQ 216_ RECLS 221_ AEPDT 226_ CALAP 231_ YLDLL 236_ NHSPH 241_ VQVKA 246_ AFNEE 251_ THSYE 256_ IRTTS 261_ RWRKH 266_ EEVFI 271_ CYGPH 276_ DNQRL 281_ FLEYG 286_ FVSVH 291_ NPHAC 296_ VYVSR 301_ EILVK 306_ YLPST 311_ DKQMD 316_ KKISI 321_ LKDHG 326_ YIENL 331_ TFGWD 336_ GPSWR 341_ LLTAL 346_ KLLCL 351_ EAEKF 356_ TCWKK 361_ VLLGE 366_ VISDT 371_ NEKTS 376_ LDIAQ 381_ KICYY 386_ FIEET 391_ NAVLQ 396_ KVSHM 401_ KDEKE 406_ ALINQ 411_ LTLVE 416_ SLWTE 421_ ELKIL 426_ RASAE 431_TLHSL
1: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins (PubMed:31308046, PubMed:35545041, PubMed:37926288). Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiation, inflammatory response and apoptosis. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha (By similarity). Through the catalysis of TBK1 monomethylation, may regulate virus-induced interferon signaling. TBK1 monomethylation enhances its interaction with MAVS, STING and IRF3, hence promoting antiviral interferon signaling (PubMed:37926288). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). In the brain, epigenetically controls quiescence of neural stem cells for sustaining a protected neural stem cell population and maintaining a stem cell reservoir for neurogenesis (By similarity). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). Through the catalysis of XRCC5/Ku70 trimethylation, regulates BAX-mediated apoptosis. SETD4-catalyzed XRCC5 methylation results in XRCC5 translocation to the cytoplasm, where it interacts with BAX, sequestering it from the mitochondria, hence preventing BAX-mediated apoptosis (PubMed:35545041)