Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2)
1_MATSP 6_ QKSPS 11_ VPKSP 16_ TPKSP 21_ PSRKK 26_ DDSFL 31_ GKLGG 36_ TLARR 41_ KKAKE 46_ VSELQ 51_ EEGMN 56_ AINLP 61_ LSPIP 66_ FELDP 71_ EDTML 76_ EENEV 81_ RTMVD 86_ PNSRS 91_ DPKLQ 96_ ELMKV 101_ LIDWI 106_ NDVLV 111_ GERII 116_ VKDLA 121_ EDLYD 126_ GQVLQ 131_ KLFEK 136_ LESEK 141_ LNVAE 146_ VTQSE 151_ IAQKQ 156_ KLQTV 161_ LEKIN 166_ ETLKL 171_ PPRSI 176_ KWNVD 181_ SVHAK 186_ SLVAI 191_ LHLLV 196_ ALSQY 201_ FRAPI 206_ RLPDH 211_ VSIQV 216_ VVVQK 221_ REGIL 226_ QSRQI 231_ QEEIT 236_ GNTEA 241_ LSGRH 246_ ERDAF 251_ DTLFD 256_ HAPDK 261_ LNVVK 266_ KTLIT 271_ FVNKH 276_ LNKLN 281_ LEVTE 286_ LETQF 291_ ADGVY 296_ LVLLM 301_ GLLEG 306_ YFVPL 311_ HSFFL 316_ TPDSF 321_ EQKVL 326_ NVSFA 331_ FELMQ 336_ DGGLE 341_ KPKPR 346_ PEDIV 351_ NCDLK 356_ STLRV 361_ LYNLF 366_TKYRN
1: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047)