4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4)
1_MAECG 6_ ASGSG 11_ SSGDS 16_ LDKSI 21_ TLPPD 26_ EIFRN 31_ LENAK 36_ RFAID 41_ IGGSL 46_ TKLAY 51_ YSTVQ 56_ HKVAK 61_ VRSFD 66_ HSGKD 71_ TEREH 76_ EPPYE 81_ ISVQE 86_ EITAR 91_ LHFIK 96_ FENTY 101_ IEACL 106_ DFIKD 111_ HLVNT 116_ ETKVI 121_ QATGG 126_ GAYKF 131_ KDLIE 136_ EKLRL 141_ KVDKE 146_ DVMTC 151_ LIKGC 156_ NFVLK 161_ NIPHE 166_ AFVYQ 171_ KDSDP 176_ EFRFQ 181_ TNHPH 186_ IFPYL 191_ LVNIG 196_ SGVSI 201_ VKVET 206_ EDRFE 211_ WVGGS 216_ SIGGG 221_ TFWGL 226_ GALLT 231_ KTKKF 236_ DELLH 241_ LASRG 246_ QHSNV 251_ DMLVR 256_ DVYGG 261_ AHQTL 266_ GLSGN 271_ LIASS 276_ FGKSA 281_ TADQE 286_ FSKED 291_ MAKSL 296_ LHMIS 301_ NDIGQ 306_ LACLH 311_ ARLHS 316_ LDRVY 321_ FGGFF 326_ IRGHP 331_ VTMRT 336_ ITYSI 341_ NFFSK 346_ GEVQA 351_ LFLRH 356_ EGYLG 361_ AIGAF 366_ LKGAE 371_ QDNPN 376_ QYSWG 381_ ENYAG 386_ SSGLM 391_ SASPE 396_ LGPAQ 401_ RARSG 406_ TFDLL 411_ EMDRL 416_ ERPLV 421_ DLPLL 426_ LDPPS 431_ YVPDT 436_ VDLTD 441_ DALAR 446_ KYWLT 451_ CFEEA 456_ LDGVV 461_ KRAVA 466_ SQPDS 471_ VDAAE 476_ RAEKF 481_ RQKYW 486_ NKLQT 491_ LRQQP 496_ FAYGT 501_ LTVRS 506_ LLDTR 511_ EHCLN 516_ EFNFP 521_ DPYSK 526_ VKQRE 531_ NGVAL 536_ RCFPG 541_ VVRSL 546_ DALGW 551_ EERQL 556_ ALVKG 561_ LLAGN 566_ VFDWG 571_ AKAVS 576_ AVLES 581_ DPYFG 586_ FEEAK 591_ RKLQE 596_ RPWLV 601_ DSYSE 606_ WLQRL 611_ KGPPH 616_ KCALI 621_ FADNS 626_ GIDII 631_ LGVFP 636_ FVREL 641_ LLRGT 646_ EVILA 651_ CNSGP 656_ ALNDV 661_ THSES 666_ LIVAE 671_ RIAGM 676_ DPVVH 681_ SALQE 686_ ERLLL 691_ VQTGS 696_ SSPCL 701_ DLSRL 706_ DKGLA 711_ ALVRE 716_ RGADL 721_ VVIEG 726_ MGRAV 731_ HTNYH 736_ AALRC 741_ ESLKL 746_ AVIKN 751_ AWLAE 756_ RLGGR 761_ LFSVI 766_FKYEV
1: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable)