Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2)
1_MSRQN 6_ LVALT 11_ VTTLL 16_ GVAVG 21_ GFVLW 26_ KGIQR 31_ RRRSK 36_ TSPVT 41_ QQPQQ 46_ KVLGS 51_ RELPP 56_ PEDDQ 61_ LHSSA 66_ PRSSW 71_ KERIL 76_ KAKVV 81_ TVSQE 86_ AEWDQ 91_ IEPLL 96_ RSELE 101_ DFPVL 106_ GIDCE 111_ WVNLE 116_ GKASP 121_ LSLLQ 126_ MASPS 131_ GLCVL 136_ VRLPK 141_ LICGG 146_ KTLPR 151_ TLLDI 156_ LADGT 161_ ILKVG 166_ VGCSE 171_ DASKL 176_ LQDYG 181_ LVVRG 186_ CLDLR 191_ YLAMR 196_ QRNNL 201_ LCNGL 206_ SLKSL 211_ AETVL 216_ NFPLD 221_ KSLLL 226_ RCSNW 231_ DAETL 236_ TEDQV 241_ IYAAR 246_ DAQIS 251_ VALFL 256_ HLLGY 261_ PFSRN 266_ SPGEK 271_ NDDHS 276_ SWRKV 281_ LEKCQ 286_ GVVDI 291_ PFRSK 296_ GMSRL 301_ GEEVN 306_ GEATE 311_ SQQKP 316_ RNKKS 321_ KMDGM 326_ VPGNH 331_ QGRDP 336_ RKHKR 341_ KPLGV 346_ GYSAR 351_ KSPLY 356_ DNCFL 361_ HAPDG 366_ QPLCT 371_ CDRRK 376_ AQWYL 381_ DKGIG 386_ ELVSE 391_ EPFVV 396_ KLRFE 401_ PAGRP 406_ ESPGD 411_ YYLMV 416_ KENLC 421_ VVCGK 426_ RDSYI 431_ RKNVI 436_ PHEYR 441_ KHFPI 446_ EMKDH 451_ NSHDV 456_ LLLCT 461_ SCHAI 466_ SNYYD 471_ NHLKQ 476_ QLAKE 481_ FQAPI 486_ GSEEG 491_ LRLLE 496_ DPERR 501_ QVRSG 506_ ARALL 511_ NAESL 516_ PTQRK 521_ EELLQ 526_ ALREF 531_ YNTDV 536_ VTEEM 541_ LQEAA 546_ SLETR 551_ ISNEN 556_ YVPHG 561_ LKVVQ 566_ CHSQG 571_ GLRSL 576_ MQLES 581_ RWRQH 586_ FLDSM 591_ QPKHL 596_ PQQWS 601_ VDHNH 606_ QKLLR 611_ KFGED 616_LPIQL
1: Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466)