Integrator complex subunit 7 (Int7)
1_MASNS 6_ TKSFL 11_ ADAGY 16_ GEQEL 21_ DANSA 26_ LMELD 31_ KGLRS 36_ GKLGE 41_ QCEAV 46_ VRFPR 51_ LFQKY 56_ PFPIL 61_ INSAF 66_ LKLAD 71_ VFRVG 76_ NNFLR 81_ LCVLK 86_ VTQQS 91_ EKHLE 96_ KILNV 101_ DEFVK 106_ RIFSV 111_ IHSND 116_ PVARA 121_ ITLRM 126_ LGSLA 131_ SIIPE 136_ RKNAH 141_ HSIRQ 146_ SLDSH 151_ DNVEV 156_ EAAVF 161_ AAANF 166_ SAQSK 171_ DFAVG 176_ ICNKI 181_ SEMIQ 186_ GLATP 191_ VDLKL 196_ KLIPI 201_ LQHMH 206_ HDAIL 211_ ASSAR 216_ QLLQQ 221_ LVTSY 226_ PSTKM 231_ VIVSL 236_ HTFTL 241_ LAASS 246_ LVDTP 251_ KQIQL 256_ LLQYL 261_ KNDPR 266_ KAVKR 271_ LAIQD 276_ LKLLA 281_ NKTPH 286_ TWSRE 291_ NIQAL 296_ CECAL 301_ QTPYD 306_ SLKLG 311_ MLSVL 316_ STLSG 321_ TIAIK 326_ HYFSI 331_ VPGNV 336_ SSSPR 341_ SSDLV 346_ KLAQE 351_ CCYHN 356_ NRGIA 361_ AHGVR 366_ VLTNI 371_ TVSCQ 376_ EKDLL 381_ ALEQD 386_ AVFGL 391_ ESLLV 396_ LCSQD 401_ DSPGA 406_ QATLK 411_ IALNC 416_ MVKLA 421_ KGRPH 426_ LSQSV 431_ VETLL 436_ TQLHS 441_ AQDAA 446_ RILMC 451_ HCLAA 456_ IAMQL 461_ PVLGD 466_ GMLGD 471_ LMELY 476_ KVIGR 481_ SATDK 486_ QQELL 491_ VSLAT 496_ VIFVA 501_ SQKAL 506_ SVESK 511_ AVIKQ 516_ QLESV 521_ SNGWT 526_ VYRIA 531_ RQASR 536_ MGNHD 541_ MAKEL 546_ YQSLL 551_ TQVAS 556_ EHFYF 561_ WLNSL 566_ KEFSH 571_ AEQCL 576_ TGLQE 581_ ENYSS 586_ ALSCI 591_ AESLK 596_ FYHKG 601_ IASLT 606_ AASTP 611_ LNPLS 616_ FQCEF 621_ VKLRI 626_ DLLQA 631_ FSQLI 636_ CTCNS 641_ LKTSP 646_ PPAIA 651_ TTIAM 656_ TLGND 661_ LQRCG 666_ RISNQ 671_ MKQSM 676_ EEFRS 681_ LASRY 686_ GDLYQ 691_ ASFDA 696_ DSATL 701_ RNVEL 706_ QQQSC 711_ LLISH 716_ AIEAL 721_ ILDPE 726_ SASFQ 731_ EYGST 736_ GTAHA 741_ DSEYE 746_ RRMMS 751_ VYNHV 756_ LEEVE 761_ SLNRK 766_ YTPVS 771_ YMHTA 776_ CLCNA 781_ IIALL 786_ KVPLS 791_ FQRYF 796_ FQKLQ 801_ STSIK 806_ LALSP 811_ SPRNP 816_ AEPIA 821_ VQNNQ 826_ QLALK 831_ VEGVV 836_ QHGSK 841_ PGLFR 846_ KIQSV 851_ CLNVS 856_ STLQS 861_ KSGQD 866_ YKIPI 871_ DNMTN 876_ EMEQR 881_ VEPHN 886_ DYFST 891_ QFLLN 896_ FAILG 901_ THNIT 906_ VESSV 911_ KDANG 916_ IVWKT 921_ GPRTT 926_ IFVKS 931_ LEDPY 936_ SQQIR 941_ LQQQQ 946_ AQQPL 951_ QQQQQ 956_RNAYT
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603)