Fanconi anemia group I protein (Protein FACI)
1_MDQKI 6_ LSLAA 11_ EKTAD 16_ KLQEF 21_ LQTLR 26_ EGDLT 31_ NLLQN 36_ QAVKG 41_ KVAGA 46_ LLRAI 51_ FKGSP 56_ CSEEA 61_ GTLRR 66_ RKIYT 71_ CCIQL 76_ VESGD 81_ LQKEI 86_ ASEII 91_ GLLML 96_ EAHHF 101_ PGPLL 106_ VELAN 111_ EFISA 116_ VREGS 121_ LVNGK 126_ SLELL 131_ PIILT 136_ ALATK 141_ KENLA 146_ YGKGV 151_ LSGEE 156_ CKKQL 161_ INTLC 166_ SGRWD 171_ QQYVI 176_ QLTSM 181_ FKDVP 186_ LTAEE 191_ VEFVV 196_ EKALS 201_ MFSKM 206_ NLQEI 211_ PPLVY 216_ QLLVL 221_ SSKGS 226_ RKSVL 231_ EGIIA 236_ FFSAL 241_ DKQHN 246_ EEQSG 251_ DELLD 256_ VVTVP 261_ SGELR 266_ HVEGT 271_ IILHI 276_ VFAIK 281_ LDYEL 286_ GRELV 291_ KHLKV 296_ GQQGD 301_ SNNNL 306_ SPFSI 311_ ALLLS 316_ VTRIQ 321_ RFQDQ 326_ VLDLL 331_ KTSVV 336_ KSFKD 341_ LQLLQ 346_ GSKFL 351_ QNLVP 356_ HRSYV 361_ STMIL 366_ EVVKN 371_ SVHSW 376_ DHVTQ 381_ GLVEL 386_ GFILM 391_ DSYGP 396_ KKVLD 401_ GKTIE 406_ TSPSL 411_ SRMPN 416_ QHACK 421_ LGANI 426_ LLETF 431_ KIHEM 436_ IRQEI 441_ LEQVL 446_ NRVVT 451_ RASSP 456_ ISHFL 461_ DLLSN 466_ IVMYA 471_ PLVLQ 476_ SCSSK 481_ VTEAF 486_ DYLSF 491_ LPLQT 496_ VQRLL 501_ KAVQP 506_ LLKVS 511_ MSMRD 516_ CLILV 521_ LRKAM 526_ FANQL 531_ DARKS 536_ AVAGF 541_ LLLLK 546_ NFKVL 551_ GSLSS 556_ SQCSQ 561_ SLSVS 566_ QVHVD 571_ VHSHY 576_ NSVAN 581_ ETFCL 586_ EIMDS 591_ LRRCL 596_ SQQAD 601_ VRLML 606_ YEGFY 611_ DVLRR 616_ NSQLA 621_ NSVMQ 626_ TLLSQ 631_ LKQFY 636_ EPKPD 641_ LLPPL 646_ KLEAC 651_ ILTQG 656_ DKISL 661_ QEPLD 666_ YLLCC 671_ IQHCL 676_ AWYKN 681_ TVIPL 686_ QQGEE 691_ EEEEE 696_ EAFYE 701_ DLDDI 706_ LESIT 711_ NRMIK 716_ SELED 721_ FELDK 726_ SADFS 731_ QSTSI 736_ GIKNN 741_ ICAFL 746_ VMGVC 751_ EVLIE 756_ YNFSI 761_ SSFSK 766_ NRFED 771_ ILSLF 776_ MCYKK 781_ LSDIL 786_ NEKAG 791_ KAKTK 796_ MANKT 801_ SDSLL 806_ SMKFV 811_ SSLLT 816_ ALFRD 821_ SIQSH 826_ QESLS 831_ VLRSS 836_ NEFMR 841_ YAVNV 846_ ALQKV 851_ QQLKE 856_ TGHVS 861_ GPDGQ 866_ NPEKI 871_ FQNLC 876_ DITRV 881_ LLWRY 886_ TSIPT 891_ SVEES 896_ GKKEK 901_ GKSIS 906_ LLCLE 911_ GLQKI 916_ FSAVQ 921_ QFYQP 926_ KIQQF 931_ LRALD 936_ VTDKE 941_ GEERE 946_ DADVS 951_ VTQRT 956_ AFQIR 961_ QFQRS 966_ LLNLL 971_ SSQEE 976_ DFNSK 981_ EALLL 986_ VTVLT 991_ SLSKL 996_ LEPSS 1001_ PQFVQ 1006_ MLSWT 1011_ SKICK 1016_ ENSRE 1021_ DALFC 1026_ KSLMN 1031_ LLFSL 1036_ HVSYK 1041_ SPVIL 1046_ LRDLS 1051_ QDIHG 1056_ HLGDI 1061_ DQDVE 1066_ VEKTN 1071_ HFAIV 1076_ NLRTA 1081_ APTVC 1086_ LLVLS 1091_ QAEKV 1096_ LEEVD 1101_ WLITK 1106_ LKGQV 1111_ SQETL 1116_ SEEAS 1121_ SQATL 1126_ PNQPV 1131_ EKAII 1136_ MQLGT 1141_ LLTFF 1146_ HELVQ 1151_ TALPS 1156_ GSCVD 1161_ TLLKD 1166_ LCKMY 1171_ TTLTA 1176_ LVRYY 1181_ LQVCQ 1186_ SSGGI 1191_ PKNME 1196_ KLVKL 1201_ SGSHL 1206_ TPLCY 1211_ SFISY 1216_ VQNKS 1221_ KSLNY 1226_ TGEKK 1231_ EKPAA 1236_ VATAM 1241_ ARVLR 1246_ ETKPI 1251_ PNLIF 1256_ AIEQY 1261_ EKFLI 1266_ HLSKK 1271_ SKVNL 1276_ MQHMK 1281_ LSTSR 1286_ DFKIK 1291_ GNILD 1296_ MVLRE 1301_ DGEDE 1306_ NEEGT 1311_ ASEHG 1316_ GQNKE 1321_PAKKK
1: Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789)