Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7)
1_MKIFC 6_ SRANP 11_ TTGSV 16_ EWLEE 21_ DEHYD 26_ YHQEI 31_ ARSSY 36_ ADMLH 41_ DKDRN 46_ VKYYQ 51_ GIRAA 56_ VSRVK 61_ DRGQK 66_ ALVLD 71_ IGTGT 76_ GLLSM 81_ MAVTA 86_ GADFC 91_ YAIEV 96_ FKPMA 101_ DAAVK 106_ IVEKN 111_ GFSDK 116_ IKVIN 121_ KHSTE 126_ VTVGP 131_ EGDMP 136_ CRANI 141_ LVTEL 146_ FDTEL 151_ IGEGA 156_ LPSYE 161_ HAHRH 166_ LVEEN 171_ CEAVP 176_ HRATV 181_ YAQLV 186_ ESGRM 191_ WSWNK 196_ LFPIH 201_ VQTSL 206_ GEQVI 211_ VPPVD 216_ VESCP 221_ GAPSV 226_ CDIQL 231_ NQVSP 236_ ADFTV 241_ LSDVL 246_ PMFSI 251_ DFSKQ 256_ VSSSA 261_ ACHSR 266_ RFEPL 271_ TSGRA 276_ QVVLS 281_ WWDIE 286_ MDPEG 291_ KIKCT 296_ MAPFW 301_ AHSDP 306_ EEMQW 311_ RDHWM 316_ QCVYF 321_ LPQEE 326_ PVVQG 331_ SALYL 336_ VAHHD 341_ DYCVW 346_ YSLQR 351_ TSPEK 356_ NERVR 361_ QMRPV 366_ CDCQA 371_ HLLWN 376_ RPRFG 381_ EINDQ 386_ DRTDR 391_ YVQAL 396_ RTVLK 401_ PDSVC 406_ LCVSD 411_ GSLLS 416_ VLAHH 421_ LGVEQ 426_ VFTVE 431_ SSAAS 436_ HKLLR 441_ KIFKA 446_ NHLED 451_ KINII 456_ EKRPE 461_ LLTNE 466_ DLQGR 471_ KVSLL 476_ LGEPF 481_ FTTSL 486_ LPWHN 491_ LYFWY 496_ VRTAV 501_ DQHLG 506_ PGAMV 511_ MPQAA 516_ SLHAV 521_ VVEFR 526_ DLWRI 531_ RSPCG 536_ DCEGF 541_ DVHIM 546_ DDMIK 551_ RALDF 556_ RESRE 561_ AEPHP 566_ LWEYP 571_ CRSLS 576_ EPWQI 581_ LTFDF 586_ QQPVP 591_ LQPLC 596_ AEGTV 601_ ELRRP 606_ GQSHA 611_ AVLWM 616_ EYHLT 621_ PECTL 626_ STGLL 631_ EPADP 636_ EGGCC 641_ WNPHC 646_ KQAVY 651_ FFSPA 656_ PDPRA 661_ LLGGP 666_ RTVSY 671_ AVEFH 676_ PDTGD 681_ IIMEF 686_RHADT
1: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo