Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95)
1_MKIFS 6_ ESHKT 11_ VFVVD 16_ HCPYM 21_ AESCR 26_ QHVEF 31_ DMLVK 36_ NRTQG 41_ IIPLA 46_ PISKS 51_ LWTCS 56_ VESSM 61_ EYCRI 66_ MYDIF 71_ PFKKL 76_ VNFIV 81_ SDSGA 86_ HVLNS 91_ WTQED 96_ QNLQE 101_ LMAAL 106_ AAVGP 111_ PNPRA 116_ DPECC 121_ SILHG 126_ LVAAV 131_ ETLCK 136_ ITEYQ 141_ HEART 146_ LLMEN 151_ AERVG 156_ NRGRI 161_ ICITN 166_ AKSDS 171_ HVRML 176_ EDCVQ 181_ ETIHE 186_ HNKLA 191_ ANSDH 196_ LMQIQ 201_ KCELV 206_ LIHTY 211_ PVGED 216_ SLVSD 221_ RSKKE 226_ LSPVL 231_ TSEVH 236_ SVRAG 241_ RHLAT 246_ KLNIL 251_ VQQHF 256_ DLAST 261_ TITNI 266_ PMKEE 271_ QHANT 276_ SANYD 281_ VELLH 286_ HKDAH 291_ VDFLK 296_ SGDSH 301_ LGGGS 306_ REGSF 311_ KETIT 316_ LKWCT 321_ PRTNN 326_ IELHY 331_ CTGAY 336_ RISPV 341_ DVNSR 346_ PSSCL 351_ TNFLL 356_ NGRSV 361_ LLEQP 366_ RKSGS 371_ KVISH 376_ MLSSH 381_ GGEIF 386_ LHVLS 391_ SSRSI 396_ LEDPP 401_ SISEG 406_ CGGRV 411_ TDYRI 416_ TDFGE 421_ FMREN 426_ RLTPF 431_ LDPRY 436_ KIDGS 441_ LEVPL 446_ ERAKD 451_ QLEKH 456_ TRYWP 461_ MIISQ 466_ TTIFN 471_ MQAVV 476_ PLASV 481_ IVKES 486_ LTEED 491_ VLNCQ 496_ KTIYN 501_ LVDME 506_ RKNDP 511_ LPIST 516_ VGTRG 521_ KGPKR 526_ DEQYR 531_ IMWNE 536_ LETLV 541_ RAHIN 546_ NSEKH 551_ QRVLE 556_ CLMAC 561_ RSKPP 566_ EEEER 571_ KKRGR 576_ KREDK 581_ EDKSE 586_ KAVKD 591_ YEQEK 596_ SWQDS 601_ ERLKG 606_ ILERG 611_ KEELA 616_ EAEII 621_ KDSPD 626_ SPEPP 631_ NKKPL 636_ VEMDE 641_ TPQVE 646_ KSKGP 651_ VSLLS 656_ LWSNR 661_ INTAN 666_ SRKHQ 671_ EFAGR 676_ LNSVN 681_ NRAEL 686_ YQHLK 691_ EENGM 696_ ETTEN 701_GKASR
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling (PubMed:23097494, PubMed:23904267). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (PubMed:23097494, PubMed:23904267)