ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb)
1_MSHLP 6_ MKLLR 11_ KKIEK 16_ RNLKL 21_ RQRNL 26_ KFQGA 31_ SNLTL 36_ SETQN 41_ GDVSE 46_ ETMGS 51_ RKVKK 56_ SKQKP 61_ MNVGL 66_ SETQN 71_ GGMSQ 76_ EAVGN 81_ IKVTK 86_ SPQKS 91_ TVLTN 96_ GEAAM 101_ QSSNS 106_ ESKKK 111_ KKKKR 116_ KMVND 121_ AEPDT 126_ KKAKT 131_ ENKGK 136_ SEEES 141_ AETTK 146_ ETENN 151_ VEKPD 156_ NDEDE 161_ SEVPS 166_ LPLGL 171_ TGAFE 176_ DTSFA 181_ SLCNL 186_ VNENT 191_ LKAIK 196_ EMGFT 201_ NMTEI 206_ QHKSI 211_ RPLLE 216_ GRDLL 221_ AAAKT 226_ GSGKT 231_ LAFLI 236_ PAVEL 241_ IVKLR 246_ FMPRN 251_ GTGVL 256_ ILSPT 261_ RELAM 266_ QTFGV 271_ LKELM 276_ THHVH 281_ TYGLI 286_ MGGSN 291_ RSAEA 296_ QKLGN 301_ GINII 306_ VATPG 311_ RLLDH 316_ MQNTP 321_ GFMYK 326_ NLQCL 331_ VIDEA 336_ DRILD 341_ VGFEE 346_ ELKQI 351_ IKLLP 356_ TRRQT 361_ MLFSA 366_ TQTRK 371_ VEDLA 376_ RISLK 381_ KEPLY 386_ VGVDD 391_ DKANA 396_ TVDGL 401_ EQGYV 406_ VCPSE 411_ KRFLL 416_ LFTFL 421_ KKNRK 426_ KKLMV 431_ FFSSC 436_ MSVKY 441_ HYELL 446_ NYIDL 451_ PVLAI 456_ HGKQK 461_ QNKRT 466_ TTFFQ 471_ FCNAD 476_ SGTLL 481_ CTDVA 486_ ARGLD 491_ IPEVD 496_ WIVQY 501_ DPPDD 506_ PKEYI 511_ HRVGR 516_ TARGL 521_ NGRGH 526_ ALLIL 531_ RPEEL 536_ GFLRY 541_ LKQSK 546_ VPLSE 551_ FDFSW 556_ SKISD 561_ IQSQL 566_ EKLIE 571_ KNYFL 576_ HKSAQ 581_ EAYKS 586_ YIRAY 591_ DSHSL 596_ KQIFN 601_ VNNLN 606_ LPQVA 611_ LSFGF 616_ KVPPF 621_ VDLNV 626_ NSNEG 631_ KQKKR 636_ GGGGG 641_ FGYQK 646_ TKKVE 651_ KSKIF 656_ KHISK 661_KSSDS
1: ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity)