Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)
1_MAKVS 6_ VLNVA 11_ VLENP 16_ SPFHS 21_ PFRFE 26_ ISFEC 31_ SEALA 36_ DDLEW 41_ KIIYV 46_ GSAES 51_ EEFDQ 56_ ILDSV 61_ LVGPV 66_ PAGRH 71_ MFVFQ 76_ ADAPN 81_ PSLIP 86_ ETDAV 91_ GVTVV 96_ LITCT 101_ YHGQE 106_ FIRVG 111_ YYVNN 116_ EYLNP 121_ ELREN 126_ PPMKP 131_ DFSQL 136_ QRNIL 141_ ASNPR 146_ VTRFH 151_ INWDN 156_ NMDRL 161_ EAIET 166_ QDPSL 171_ GCGLP 176_ LNCTP 181_ IKGLG 186_ LPGCI 191_ PGLLP 196_ENSMD
1: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904)