Integrator complex subunit 10 (Int10)
1_MSAQG 6_ DCEFL 11_ VQRAR 16_ ELVPQ 21_ DLWAA 26_ KAWLI 31_ TARSL 36_ YPADF 41_ NIQYE 46_ MYTIE 51_ RNAER 56_ TATAG 61_ RLLYD 66_ MFVNF 71_ PDQPV 76_ VWREI 81_ SIITS 86_ ALRND 91_ SQDKQ 96_ TQFLR 101_ SLFET 106_ LPGRV 111_ QCEML 116_ LKVTE 121_ QCFNT 126_ LERSE 131_ MLLLL 136_ LRRFP 141_ ETVVQ 146_ HGVGL 151_ GEALL 156_ EAETI 161_ EEQES 166_ PVNCF 171_ RKLFV 176_ CDVLP 181_ LIINN 186_ HDVRL 191_ PANLL 196_ YKYLN 201_ KAAEF 206_ YINYV 211_ TRSTQ 216_ IENQH 221_ QGAQD 226_ TSDLM 231_ SPSKR 236_ SSQKY 241_ IIEGL 246_ TEKSS 251_ QIVDP 256_ WERLF 261_ KILNV 266_ VGMRC 271_ EWQMD 276_ KGRRS 281_ YGDIL 286_ HRMKD 291_ LCRYM 296_ NNFDS 301_ EAHAK 306_ YKNQV 311_ VYSTM 316_ LVFFK 321_ NAFQY 326_ VNSIQ 331_ PSLFQ 336_ GPNAP 341_ SQVPL 346_ VLLED 351_ VSNVY 356_ GDVEI 361_ DRNKH 366_ IHKKR 371_ KLAEG 376_ REKTM 381_ SSDDE 386_ DCSAK 391_ GRNRH 396_ IVVNK 401_ AELAN 406_ STEVL 411_ ESFKL 416_ ARESW 421_ ELLYS 426_ LEFLD 431_ KEFTR 436_ ICLAW 441_ KTDTW 446_ LWLRI 451_ FLTDM 456_ IIYQG 461_ QYKKA 466_ IASLH 471_ HLAAL 476_ QGSIS 481_ QPQIT 486_ GQGTL 491_ EHQRA 496_ LIQLA 501_ TCHFA 506_ LGEYR 511_ MTCEK 516_ VLDLM 521_ CYMVL 526_ PIQDG 531_ GKSQE 536_ EPSKV 541_ KPKFR 546_ KGSDL 551_ KLLPC 556_ TSKAI 561_ MPYCL 566_ HLMLA 571_ CFKLR 576_ AFTDN 581_ RDDMA 586_ LGHVI 591_ VLLQQ 596_ EWPRG 601_ ENLFL 606_ KAVNK 611_ ICQQG 616_ NFQYE 621_ NFFNY 626_ VTNID 631_ MLEEF 636_ AYLRT 641_ QEGGK 646_ IHLEL 651_ LPNQG 656_ MLIKH 661_ HTVTR 666_ GITKG 671_ VKEDF 676_ RLAME 681_ RQVSR 686_ CGENL 691_ MVVLH 696_ RFCIN 701_EKILL
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:32647223). Within the integrator complex, INTS10 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)