DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)
1_MANEE 6_ DDPVV 11_ QEIDV 16_ YLAKS 21_ LAEKL 26_ YLFQY 31_ PVRPA 36_ SMTYD 41_ DIPHL 46_ SAKIK 51_ PKQQK 56_ VELEM 61_ AIDTL 66_ NPNYC 71_ RSKGE 76_ QIALN 81_ VDGAC 86_ ADETS 91_ TYSSK 96_ LMDKQ 101_ TFCSS 106_ QTTSN 111_ TSRYA 116_ AALYR 121_ QGELH 126_ LTPLH 131_ GILQL 136_ RPSFS 141_ YLDKA 146_ DAKHR 151_ EREAA 156_ NEAGD 161_ SSQDE 166_ AEDDV 171_ KQITV 176_ RFSRP 181_ ESEQA 186_ RQRRV 191_ QSYEF 196_ LQKKH 201_ AEEPW 206_ VHLHY 211_ YGLRD 216_ SRSEH 221_ ERQYL 226_ LCPGS 231_ SGVEN 236_ TELVK 241_ SPSEY 246_ LMMLM 251_ PPSQE 256_ EEKDK 261_ PVAPS 266_ NVLSM 271_ AQLRT 276_ LPLAD 281_ QIKIL 286_ MKNVK 291_ VMPFA 296_ NLMSL 301_ LGPSI 306_ DSVAV 311_ LRGIQ 316_ KVAML 321_ VQGNW 326_ VVKSD 331_ ILYPK 336_ DSSSP 341_ HSGVP 346_ AEVLC 351_ RGRDF 356_ VMWKF 361_ TQSRW 366_ VVRKE 371_ VATVT 376_ KLCAE 381_ DVKDF 386_ LEHMA 391_ VVRIN 396_ KGWEF 401_ ILPYD 406_ GEFIK 411_ KHPDV 416_ VQRQH 421_ MLWTG 426_ IQAKL 431_ EKVYN 436_ LVKET 441_ MPKKP 446_ DAQSG 451_ PAGLV 456_ CGDQR 461_ IQVAK 466_ TKAQQ 471_ NHALL 476_ ERELQ 481_ RRKEQ 486_ LRVPA 491_ VPPGV 496_ RIKEE 501_ PVSEE 506_ GEEDE 511_ EQEAE 516_ EEPMD 521_ TSPSG 526_ LHSKL 531_ ANGLP 536_ LGRAA 541_ GTDSF 546_ NGHPP 551_ QGCAS 556_ TPVAR 561_ ELKAF 566_ VEATF 571_ QRQFV 576_ LTLSE 581_ LKRLF 586_ NLHLA 591_ SLPPG 596_ HTLFS 601_ GISDR 606_ MLQDT 611_ VLAAG 616_ CKQIL 621_ VPFPP 626_ QTAAS 631_ PDEQK 636_ VFALW 641_ ESGDM 646_ SDQHR 651_ QVLLE 656_ IFSKN 661_ YRVRR 666_ NMIQS 671_ RLTQE 676_ CGEDL 681_ SKQEV 686_ DKVLK 691_ DCCVS 696_ YGGMW 701_YLKGT
1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370)