THAP domain-containing protein 1
1_MVQSC 6_ SAYGC 11_ KNRYD 16_ KDKPV 21_ SFHKF 26_ PLTRP 31_ SLCKE 36_ WEAAV 41_ RRKNF 46_ KPTKY 51_ SSICS 56_ EHFTP 61_ DCFKR 66_ ECNNK 71_ LLKEN 76_ AVPTI 81_ FLCTE 86_ PHDKK 91_ EDLLE 96_ PQEQL 101_ PPPPL 106_ PPPVS 111_ QVDAA 116_ IGLLM 121_ PPLQT 126_ PVNLS 131_ VFCDH 136_ NYTVE 141_ DTMHQ 146_ RKRIH 151_ QLEQQ 156_ VEKLR 161_ KKLKT 166_ AQQRC 171_ RRQER 176_ QLEKL 181_ KEVVH 186_ FQKEK 191_ DDVSE 196_ RGYVI 201_ LPNDY 206_FEIVE
1: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis