E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)
1_MENSD 6_ SNDKG 11_ SGDQS 16_ AAQRR 21_ SQMDR 26_ LDREE 31_ AFYQF 36_ VNNLS 41_ EEDYR 46_ LMRDN 51_ NLLGT 56_ PGEST 61_ EEELL 66_ RRLQQ 71_ IKEGP 76_ PPQNS 81_ DENRG 86_ GDSSD 91_ DVSNG 96_ DSIID 101_ WLNSV 106_ RQTGN 111_ TTRSG 116_ QRGNQ 121_ SWRAV 126_ SRTNP 131_ NSGDF 136_ RFSLE 141_ INVNR 146_ NNGSQ 151_ NSENE 156_ NEPSA 161_ RRSSG 166_ ENVEN 171_ NSQRQ 176_ VENPR 181_ SESTS 186_ ARPSR 191_ SERNS 196_ TEALT 201_ EVPPT 206_ RGQRR 211_ ARSRS 216_ PDHRR 221_ TRARA 226_ ERSRS 231_ PLHPM 236_ SEIPR 241_ RSHHS 246_ ISSQT 251_ FEHPL 256_ VNETE 261_ GSSRT 266_ RHHVT 271_ LRQQI 276_ SGPEL 281_ LSRGL 286_ FAASG 291_ TRNAS 296_ QGAGS 301_ SDTAA 306_ SGEST 311_ GSGQR 316_ PPTIV 321_ LDLQV 326_ RRVRP 331_ GEYRQ 336_ RDSIA 341_ SRTRS 346_ RSQTP 351_ NNTVT 356_ YESER 361_ GGFRR 366_ TFSRS 371_ ERAGV 376_ RTYVS 381_ TIRIP 386_ IRRIL 391_ NTGLS 396_ ETTSV 401_ AIQTM 406_ LRQIM 411_ TGFGE 416_ LSYFM 421_ YSDSD 426_ SEPTG 431_ SVSNR 436_ NMERA 441_ ESRSG 446_ RGGSG 451_ GGSSS 456_ GSSSS 461_ SSSSS 466_ SSSSS 471_ SSSSS 476_ SPSSS 481_ SGGES 486_ SETSS 491_ DLFEG 496_ SNEGS 501_ SSSGS 506_ SGARR 511_ EGRHR 516_ APVTF 521_ DESGS 526_ LPFLS 531_ LAQFF 536_ LLNED 541_ DDDQP 546_ RGLTK 551_ EQIDN 556_ LAMRS 561_ FGEND 566_ ALKTC 571_ SVCIT 576_ EYTEG 581_ NKLRK 586_ LPCSH 591_ EYHVH 596_ CIDRW 601_ LSENS 606_ TCPIC 611_ RRAVL 616_ASGNR
1: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals