Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4)
1_MESPE 6_ EPGAS 11_ MDENY 16_ FVNYT 21_ FKDRS 26_ HSGRV 31_ AQGIM 36_ KLCLE 41_ EELFA 46_ DVTIS 51_ VEGRE 56_ FQLHR 61_ LVLSA 66_ QSCFF 71_ RSMFT 76_ SNLKE 81_ AHNRV 86_ IVLQD 91_ VSESV 96_ FQLLV 101_ DYIYH 106_ GTVKL 111_ RAEEL 116_ QEIYE 121_ VSDMY 126_ QLTSL 131_ FEECS 136_ RFLAR 141_ TVQVG 146_ NCLQV 151_ MWLAD 156_ RHSDP 161_ ELYTA 166_ AKHCA 171_ KTHLA 176_ QLQNT 181_ EEFLH 186_ LPHRL 191_ LTDII 196_ SDGVP 201_ CSQNP 206_ TEAIE 211_ AWINF 216_ NKEER 221_ EAFAE 226_ SLRTS 231_ LKEIG 236_ ENVHI 241_ YLIGK 246_ ESSRT 251_ HSLAV 256_ SLHCA 261_ EDDSI 266_ SVSGQ 271_ NSLCH 276_ QITAA 281_ CKHGG 286_ DLYVV 291_ GGSIP 296_ RRMWK 301_ CNNAT 306_ VDWEW 311_ CAPLP 316_ RDRLQ 321_ HTLVS 326_ VPGKD 331_ AIYSL 336_ GGKTL 341_ QDTLS 346_ NAVIY 351_ YRVGD 356_ NVWTE 361_ TTQLE 366_ VAVSG 371_ AAGAN 376_ LNGII 381_ YLLGG 386_ EENDL 391_ DFFTK 396_ PSRLI 401_ QCFDT 406_ ETDKC 411_ HVKPY 416_ VLPFA 421_ GRMHA 426_ AVHKD 431_ LVFIV 436_ AEGDS 441_ LVCYN 446_ PLLDS 451_ FTRLC 456_ LPEAW 461_ SSAPS 466_ LWKIA 471_ SCNGS 476_ IYVFR 481_ DRYKK 486_ GDANT 491_ YKLDP 496_ ATSAV 501_ TVTRG 506_ IKVLL 511_TNLQF
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation (PubMed:33417871). RCOR1 is likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1 (PubMed:33417871). Also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1 (PubMed:36997086). Degradation is dependent on the presence of an ELM2 domain in the target proteins (PubMed:36997086)