E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL)
1_MAVTE 6_ ASLLR 11_ QCPLL 16_ LPQNR 21_ SKTVY 26_ EGFIS 31_ AQGRD 36_ FHLRI 41_ VLPED 46_ LQLKN 51_ ARLLC 56_ SWQLR 61_ TILSG 66_ YHRIV 71_ QQRMQ 76_ HSPDL 81_ MSFMM 86_ ELKML 91_ LEVAL 96_ KNRQE 101_ LYALP 106_ PPPQF 111_ YSSLI 116_ EEIGT 121_ LGWDK 126_ LVYAD 131_ TCFST 136_ IKLKA 141_ EDASG 146_ REHLI 151_ TLKLK 156_ AKYPA 161_ ESPDY 166_ FVDFP 171_ VPFCA 176_ SWTPQ 181_ SSLIS 186_ IYSQF 191_ LAAIE 196_ SLKAF 201_ WDVMD 206_ EIDEK 211_ TWVLE 216_ PEKPP 221_ RSATA 226_ RRIAL 231_ GNNVS 236_ INIEV 241_ DPRHP 246_ TMLPE 251_ CFFLG 256_ ADHVV 261_ KPLGI 266_ KLSRN 271_ IHLWD 276_ PENSV 281_ LQNLK 286_ DVLEI 291_ DFPAR 296_ AILEK 301_ SDFTM 306_ DCGIC 311_ YAYQL 316_ DGTIP 321_ DQVCD 326_ NSQCG 331_ QPFHQ 336_ ICLYE 341_ WLRGL 346_ LTSRQ 351_ SFNII 356_ FGECP 361_ YCSKP 366_ITLKM
1: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth