Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16)
1_MATSL 6_ GSNTY 11_ NRQNW 16_ EDADF 21_ PILCQ 26_ TCLGE 31_ NPYIR 36_ MTKEK 41_ YGKEC 46_ KICAR 51_ PFTVF 56_ RWCPG 61_ VRMRF 66_ KKTEV 71_ CQTCS 76_ KLKNV 81_ CQTCL 86_ LDLEY 91_ GLPIQ 96_ VRDAG 101_ LSFKD 106_ DMPKS 111_ DVNKE 116_ YYTQN 121_ MEREI 126_ SNSDG 131_ TRPVG 136_ MLGKA 141_ TSTSD 146_ MLLKL 151_ ARTTP 156_ YYKRN 161_ RPHIC 166_ SFWVK 171_ GECKR 176_ GEECP 181_ YRHEK 186_ PTDPD 191_ DPLAD 196_ QNIKD 201_ RYYGI 206_ NDPVA 211_ DKLLK 216_ RASTM 221_ PRLDP 226_ PEDKT 231_ ITTLY 236_ VGGLG 241_ DTITE 246_ TDLRN 251_ HFYQF 256_ GEIRT 261_ ITVVQ 266_ RQQCA 271_ FIQFA 276_ TRQAA 281_ EVAAE 286_ KSFNK 291_ LIVNG 296_ RRLNV 301_ KWGRS 306_ QAARG 311_ KEKEK 316_ DGTTD 321_ SGIKL 326_ EPVPG 331_ LPGAL 336_ PPPPA 341_ AEEEA 346_ SANYF 351_ NLPPS 356_ GPPAV 361_ VNIAL 366_ PPPPG 371_ IAPPP 376_ PPGFG 381_ PHMFH 386_ PMGPP 391_ PPFMR 396_ APGPI 401_ HYPSQ 406_ DPQRM 411_GAHAG
1: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses