Arginine and glutamate-rich protein 1
1_MGRSR 6_ SRSSS 11_ RSKHT 16_ KSSKH 21_ NKKRS 26_ RSRSR 31_ SRDKE 36_ RVRKR 41_ SKSRE 46_ SKRNR 51_ RRESR 56_ SRSRS 61_ TNTAV 66_ SRRER 71_ DRERA 76_ SSPPD 81_ RIDIF 86_ GRTVS 91_ KRSSL 96_ DEKQK 101_ REEEE 106_ KKAEF 111_ ERQRK 116_ IRQQE 121_ IEEKL 126_ IEEET 131_ ARRVE 136_ ELVAK 141_ RVEEE 146_ LEKRK 151_ DEIER 156_ EVLRR 161_ VEEAK 166_ RIMEK 171_ QLLEE 176_ LERQR 181_ QAELA 186_ AQKAR 191_ EEEER 196_ AKREE 201_ LERIL 206_ EENNR 211_ KIAEA 216_ QAKLA 221_ EEQLR 226_ IVEEQ 231_ RKIHE 236_ ERMKL 241_ EQERQ 246_ RQQKE 251_ EQKII 256_ LGKGK 261_ SRPKL 266_SFSLK
1: Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (PubMed:27899669, PubMed:36533631). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (PubMed:36533631). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (By similarity). Regulates splicing of genes involved in neurogenesis and chromatin organization (By similarity). Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes (PubMed:21454576). Can act in cooperation with MED1 (PubMed:21454576)