Intraflagellar transport protein 57 homolog (Dermal papilla-derived protein 8) (Estrogen-related receptor beta-like protein 1) (HIP1-interacting protein) (MHS4R2)
1_MTAAL 6_ AVVTT 11_ SGLED 16_ GVPRS 21_ RGEGT 26_ GEVVL 31_ ERGPG 36_ AAYHM 41_ FVVME 46_ DLVEK 51_ LKLLR 56_ YEEEF 61_ LRKSN 66_ LKAPS 71_ RHYFA 76_ LPTNP 81_ GEQFY 86_ MFCTL 91_ AAWLI 96_ NKAGR 101_ PFEQP 106_ QEYDD 111_ PNATI 116_ SNILS 121_ ELRSF 126_ GRTAD 131_ FPPSK 136_ LKSGY 141_ GEHVC 146_ YVLDC 151_ FAEEA 156_ LKYIG 161_ FTWKR 166_ PIYPV 171_ EELEE 176_ ESVAE 181_ DDAEL 186_ TLNKV 191_ DEEFV 196_ EEETD 201_ NEENF 206_ IDLNV 211_ LKAQT 216_ YHLDM 221_ NETAK 226_ QEDIL 231_ ESTTD 236_ AAEWS 241_ LEVER 246_ VLPQL 251_ KVTIR 256_ TDNKD 261_ WRIHV 266_ DQMHQ 271_ HRSGI 276_ ESALK 281_ ETKGF 286_ LDKLH 291_ NEITR 296_ TLEKI 301_ SSREK 306_ YINNQ 311_ LENLV 316_ QEYRA 321_ AQAQL 326_ SEAKE 331_ RYQQG 336_ NGGVT 341_ ERTRL 346_ LSEVM 351_ EELEK 356_ VKQEM 361_ EEKGS 366_ SMTDG 371_ APLVK 376_ IKQSL 381_ TKLKQ 386_ ETVEM 391_ DIRIG 396_ IVEHT 401_ LLQSK 406_ LKEKS 411_ NMTRN 416_ MHATV 421_IPEPA
1: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear