E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)
1_MEEGN 6_ NNEEV 11_ IHLNN 16_ FHCHR 21_ GQEWI 26_ NLRDG 31_ PITIS 36_ DSSDE 41_ ERIPM 46_ LVTPA 51_ PQQHE 56_ EEDLD 61_ DDVIL 66_ TEDDS 71_ EDDYG 76_ EFLDL 81_ GPPGI 86_ SEFTK 91_ PSGQT 96_ EREPK 101_ PGPSH 106_ NQAAN 111_ DIVNP 116_ RSEQK 121_ VIILE 126_ EGSLL 131_ YTESD 136_ PLETQ 141_ NQSSE 146_ DSETE 151_ LLSNL 156_ GESAA 161_ LADDQ 166_ AIEED 171_ CWLDH 176_ PYFQS 181_ LNQQP 186_ REITN 191_ QVVPQ 196_ ERQPE 201_ AELGR 206_ LLFQH 211_ EFPGP 216_ AFPRP 221_ EPQQG 226_ GISGP 231_ SSPQP 236_ AHPLG 241_ EFEDQ 246_ QLASD 251_ DEEPG 256_ PAFPM 261_ QESQE 266_ PNLEN 271_ IWGQE 276_ AAEVD 281_ QELVE 286_ LLVKE 291_ TEARF 296_ PDVAN 301_ GFIEE 306_ IIHFK 311_ NYYDL 316_ NVLCN 321_ FLLEN 326_ PDYPK 331_ REDRI 336_ IINPS 341_ SSLLA 346_ SQDET 351_ KLPKI 356_ DFFDY 361_ SKLTP 366_ LDQRC 371_ FIQAA 376_ DLLMA 381_ DFKVL 386_ SSQDI 391_ KWALH 396_ ELKGH 401_ YAITR 406_ KALSD 411_ AIKKW 416_ QELSP 421_ ETSGK 426_ RKKRK 431_ QMNQY 436_ SYIDF 441_ KFEQG 446_ DIKIE 451_ KRMFF 456_ LENKR 461_ RHCRS 466_ YDRRA 471_ LLPAV 476_ QQEQE 481_ FYEQK 486_ IKEMA 491_ EHEDF 496_ LLALQ 501_ MNEEQ 506_ YQKDG 511_ QLIEC 516_ RCCYG 521_ EFPFE 526_ ELTQC 531_ ADAHL 536_ FCKEC 541_ LIRYA 546_ QEAVF 551_ GSGKL 556_ ELSCM 561_ EGSCT 566_ CSFPT 571_ SELEK 576_ VLPQT 581_ ILYKY 586_ YERKA 591_ EEEVA 596_ AAYAD 601_ ELVRC 606_ PSCSF 611_ PALLD 616_ SDVKR 621_ FSCPN 626_ PHCRK 631_ ETCRK 636_ CQGLW 641_ KEHNG 646_ LTCEE 651_ LAEKD 656_ DIKYR 661_ TSIEE 666_ KMTAA 671_ RIRKC 676_ HKCGT 681_ GLIKS 686_ EGCNR 691_ MSCRC 696_ GAQMC 701_ YLCRV 706_ SINGY 711_ DHFCQ 716_ HPRSP 721_ GAPCQ 726_ ECSRC 731_ SLWTD 736_ PTEDD 741_ EKLIE 746_ EIQKE 751_ AEEEQ 756_ KRKNG 761_ ENTFK 766_ RIGPP 771_ LEKPV 776_ EKVQR 781_ VEALP 786_ RPVPQ 791_ NLPQP 796_ QMPPY 801_ AFAHP 806_ PFPLP 811_ PVRPV 816_ FNNFP 821_ LNMGP 826_ IPAPY 831_ VPPLP 836_ NVRVN 841_ YDFGP 846_ IHMPL 851_ EHNLP 856_ MHFGP 861_QPRHR
1: E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination (PubMed:34998453). Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9 (PubMed:15107846, PubMed:19893624). In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Also participates in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition (PubMed:25484083). Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (PubMed:24945773). Plays aso an essential role in spermatogenesis and male fertility (By similarity). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (By similarity). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (By similarity)
2: Inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis