Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)
1_MQSCE 6_ SSGDS 11_ ADDPL 16_ SRGLR 21_ RRGQP 26_ RVVVI 31_ GAGLA 36_ GLAAA 41_ KALLE 46_ QGFTD 51_ VTVLE 56_ ASSHI 61_ GGRVQ 66_ SVKLG 71_ HATFE 76_ LGATW 81_ IHGSH 86_ GNPIY 91_ HLAEA 96_ NGLLE 101_ ETTDG 106_ ERSVG 111_ RISLY 116_ SKNGV 121_ ACYLT 126_ NHGRR 131_ IPKDV 136_ VEEFS 141_ DLYNE 146_ VYNLT 151_ QEFFR 156_ HDKPV 161_ NAESQ 166_ NSVGV 171_ FTREE 176_ VRNRI 181_ RNDPD 186_ DPEAT 191_ KRLKL 196_ AMIQQ 201_ YLKVE 206_ SCESS 211_ SHSMD 216_ EVSLS 221_ AFGEW 226_ TEIPG 231_ AHHII 236_ PSGFM 241_ RVVEL 246_ LAEGI 251_ PAHVI 256_ QLGKP 261_ VRCIH 266_ WDQAS 271_ ARPRG 276_ PEIEP 281_ RGEGD 286_ HNHDT 291_ GEGGQ 296_ GGEEP 301_ RGGRW 306_ DEDEQ 311_ WSVVV 316_ ECEDC 321_ ELIPA 326_ DHVIV 331_ TVSLG 336_ VLKRQ 341_ YTSFF 346_ RPGLP 351_ TEKVA 356_ AIHRL 361_ GIGTT 366_ DKIFL 371_ EFEEP 376_ FWGPE 381_ CNSLQ 386_ FVWED 391_ EAESH 396_ TLTYP 401_ PELWY 406_ RKICG 411_ FDVLY 416_ PPERY 421_ GHVLS 426_ GWICG 431_ EEALV 436_ MEKCD 441_ DEAVA 446_ EICTE 451_ MLRQF 456_ TGNPN 461_ IPKPR 466_ RILRS 471_ AWGSN 476_ PYFRG 481_ SYSYT 486_ QVGSS 491_ GADVE 496_ KLAKP 501_ LPYTE 506_ SSKTA 511_ PMQVL 516_ FSGEA 521_ THRKY 526_ YSTTH 531_ GALLS 536_ GQREA 541_ ARLIE 546_MYRDL
1: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal