Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
1_MGPAG 6_ SLLGS 11_ GQMQI 16_ TLWGS 21_ LAAVA 26_ IFFVI 31_ TFLIF 36_ LCSSC 41_ DREKK 46_ PRQHS 51_ GDHEN 56_ LMNVP 61_ SDKEM 66_ FSRSV 71_ TSLAT 76_ DAPAS 81_ SEQNG 86_ ALTNG 91_ DILSE 96_ DSTLT 101_ CMQHY 106_ EEVQT 111_ SASDL 116_ LDSQD 121_ STGKP 126_ KCHQS 131_ RELPR 136_ IPPES 141_ AVDTM 146_ LTARS 151_ VDGDQ 156_ GLGME 161_ GPYEV 166_ LKDSS 171_ SQENM 176_ VEDCL 181_ YETVK 186_ EIKEV 191_ AAAAH 196_ LEKGH 201_ SGKAK 206_ STSAS 211_ KELPG 216_ PQTEG 221_ KAEFA 226_ EYASV 231_ DRNKK 236_ CRQSV 241_ NVESI 246_ LGNSC 251_ DPEEE 256_ APPPV 261_ PVKLL 266_ DENEN 271_ LQEKE 276_ GGEAE 281_ ESATD 286_ TTSET 291_ NKRFS 296_ SLSYK 301_ SREED 306_ PTLTE 311_ EEISA 316_ MYSSV 321_ NKPGQ 326_ LVNKS 331_ GQSLT 336_ VPEST 341_ YTSIQ 346_ GDPQR 351_ SPSSC 356_ NDLYA 361_ TVKDF 366_ EKTPN 371_ STLPP 376_ AGRPS 381_ EEPEP 386_ DYEAI 391_ QTLNR 396_ EEEKA 401_ TLGTN 406_ GHHGL 411_ VPKEN 416_ DYESI 421_ SDLQQ 426_GRDIT
1: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling