Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B)
1_MLQRG 6_ LWPWR 11_ TRLLP 16_ TPGTW 21_ RPARP 26_ WPLPP 31_ PPQVL 36_ RVKLC 41_ GNVKY 46_ YQSHH 51_ YSTVV 56_ PPDEI 61_ TVIYR 66_ HGLPL 71_ VTLTL 76_ PSRKE 81_ RCQFV 86_ VKPML 91_ STVGS 96_ FLQDL 101_ QNEDK 106_ GIKTA 111_ AIFTA 116_ DGNMI 121_ SASTL 126_ MDILL 131_ MNDFK 136_ LVINK 141_ IAYDV 146_ QCPKR 151_ EKPSN 156_ EHTAE 161_ MEHMK 166_ SLVHR 171_ LFTIL 176_ HLEES 181_ QKKRE 186_ HHLLE 191_ KIDHL 196_ KEQLQ 201_ PLEQV 206_ KAGIE 211_ AHSEA 216_ KTSGL 221_ LWAGL 226_ ALLSI 231_ QGGAL 236_ AWLTW 241_ WVYSW 246_ DIMEP 251_ VTYFI 256_ TFANS 261_ MVFFA 266_ YFIVT 271_ RQDYT 276_ YSAVK 281_ SRQFL 286_ QFFHK 291_ KSKQQ 296_ HFDVQ 301_ QYNKL 306_ KEDLA 311_ KAKES 316_ LKQAR 321_ HSLCL 326_ QMQVE 331_ELNEK
1: Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix (PubMed:31533452). MCUB is required to limit mitochondrial calcium overload during stress (PubMed:31533452). Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating (PubMed:31533452). Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism (PubMed:31533452). Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (By similarity). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells (By similarity)