PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog)
1_MANPK 6_ LLGMG 11_ LSEAE 16_ AIGAD 21_ SARFE 26_ ELLLQ 31_ ASKEL 36_ QQAQT 41_ TRPES 46_ TQIQP 51_ QPGFC 56_ IKTNS 61_ SEGKV 66_ FINIC 71_ HSPSI 76_ PPPAD 81_ VTEEE 86_ LLQML 91_ EEDQA 96_ GFRIP 101_ MSLGE 106_ PHAEL 111_ DAKGQ 116_ GCTAY 121_ DVAVN 126_ SDFYR 131_ RMQNS 136_ DFLRE 141_ LVITI 146_ AREGL 151_ EDKYN 156_ LQLNP 161_ EWRMM 166_ KNRPF 171_ MGSIS 176_ QQNIR 181_ SEQRP 186_ RIQEL 191_ GDLYT 196_ PAPGR 201_ AESGP 206_ EKPHL 211_ NLWLE 216_ APDLL 221_ LAEVD 226_ LPKLD 231_ GALGL 236_ SLEIG 241_ ENRLV 246_ MGGPQ 251_ QLYHL 256_ DAYIP 261_ LQINS 266_ HESKA 271_ AFHRK 276_ RKQLM 281_VAMPL
1: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451)