p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)
1_MELVA 6_ GCYEQ 11_ VLFGF 16_ AVHPE 21_ PEACG 26_ DHEQW 31_ TLVAD 36_ FTHHA 41_ HTASL 46_ SAVAV 51_ NSRFV 56_ VTGSK 61_ DETIH 66_ IYDMK 71_ KKIEH 76_ GALVH 81_ HSGTI 86_ TCLKF 91_ YGNRH 96_ LISGA 101_ EDGLI 106_ CIWDA 111_ KKWEC 116_ LKSIK 121_ AHKGQ 126_ VTFLS 131_ IHPSG 136_ KLALS 141_ VGTDK 146_ TLRTW 151_ NLVEG 156_ RSAFI 161_ KNIKQ 166_ NAHIV 171_ EWSPR 176_ GEQYV 181_ VIIQN 186_ KIDIY 191_ QLDTA 196_ SISGT 201_ ITNEK 206_ RISSV 211_ KFLSE 216_ SVLAV 221_ AGDEE 226_ VIRFF 231_ DCDSL 236_ VCLCE 241_ FKAHE 246_ NRVKD 251_ MFSFE 256_ IPEHH 261_ VIVSA 266_ SSDGF 271_ IKMWK 276_ LKQDK 281_ KVPPS 286_ LLCEI 291_ NTNAR 296_ LTCLG 301_ VWLDK 306_ VADMK 311_ ESLPP 316_ AAEPS 321_ PVSKE 326_ QSKIG 331_ KKEPG 336_ DTVHK 341_ EEKRS 346_ KPNTK 351_ KRGLT 356_ GDSKK 361_ ATKES 366_ GLIST 371_ KKRKM 376_ VEMLE 381_ KKRKK 386_KKIKT
1: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868)