Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)
1_MSYAE 6_ KPDEI 11_ TKDEW 16_ MEKLN 21_ NLHVQ 26_ RADMN 31_ RLIMN 36_ YLVTE 41_ GFKEA 46_ AEKFR 51_ MESGI 56_ EPSVD 61_ LETLD 66_ ERIKI 71_ REMIL 76_ KGQIQ 81_ EAIAL 86_ INSLH 91_ PELLD 96_ TNRYL 101_ YFHLQ 106_ QQHLI 111_ ELIRQ 116_ RETEA 121_ ALEFA 126_ QTQLA 131_ EQGEE 136_ SRECL 141_ TEMER 146_ TLALL 151_ AFDSP 156_ EESPF 161_ GDLLH 166_ TMQRQ 171_ KVWSE 176_ VNQAV 181_ LDYEN 186_ RESTP 191_ KLAKL 196_ LKLLL 201_ WAQNE 206_ LDQKK 211_ VKYPK 216_ MTDLS 221_KGVIE
1: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046)